protein

14-3-3 beta, 1-246aa, Human, Recombinant, E Coli

MBS203165

0.1 mg

375 USD

Recombinant Protein

14-3-3 beta, 1-246aa, Human, Recombinant, E Coli

14-3-3 beta

Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein; beta polypeptide; 14-3-3 beta; YWHAB; GW128; HS1; KCIP-1; Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein; beta polypeptide 14 3 3 protein beta/alpha; Brain protein 14 3 3 beta isoform; GW 128; HS 1; KCIP 1; KCIP1; Protein 1054; Protein kinase C inhibitor protein 1; Tyrosine 3 Monooxygenase/Tryptophan 5 Monooxygenase Activation Protein Beta Polypeptide.

14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha; 14-3-3 alpha; brain protein 14-3-3, beta isoform; epididymis secretory protein Li 1; protein 1054; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1

14-3-3 beta

YWHAB; YWHAB; HS1; GW128; YWHAA; KCIP-1; HEL-S-1; KCIP-1

1433B_HUMAN

246

MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN

> 90% by SDS - PAGE

Liquid in 20mM Tris pH 8.0, 1mM EDTA, 50mM NaCl

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli

Signal Transduction

The 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon,sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Recombinant human 14-3-3 beta was expressed in E.coli and purified by using conventional chromatography techniques.

Rodriguez LG., et al. (2005) J Cell Physiol. 202(1):285-94. Mils V., et al. (2000) Oncogene. 19(10):1257-65.

4507949

NP_003395

NM_003404.4

28 kDa (246 aa), confirmed by MALDI-TOF.

ARMS-mediated Activation Pathway 106466!!Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Adaptive Immune System Pathway 366160!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Apoptosis Pathway 105648!!Axon Guidance Pathway 105688!!Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway 187213!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Cell Cycle Pathway 198811

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

0.1 mg

375 USD