Recombinant Apolipoprotein C2 (APOC2) | MyBioSource MBS2031641 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Apolipoprotein C2 (APOC2)

catalog :

MBS2031641

quantity :

0.01 mg

price :

155 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2031641

products type :

Recombinant Protein

products full name :

Recombinant Apolipoprotein C2 (APOC2)

products short name :

[Apolipoprotein C2]

other names :

[apolipoprotein C-II; Apolipoprotein C-II; apolipoprotein C-II; apolipoprotein C-II; Apolipoprotein C2]

products gene name :

[APOC2]

other gene names :

[APOC2; APOC2; APO-CII; APOC-II; APC2; Apo-CII; ApoC-II; ProapoC-II]

uniprot entry name :

APOC2_HUMAN

host :

E Coli

sequence length :

101

sequence :

The sequence of the target protein is listed below. THEPQEDE AASTPLLTKV QESLLSYWDS AKTAAQDLYK KTSLTTVDEK IRDMYSKSTA AVSTYAEILT DQFLSLLKGD S

purity :

>95%

form :

Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

image1 heading :

SDS-Page

other info1 :

Predicted isoelectric point: 4.6. Predicted Molecular Mass: 12.5kDa. Endotoxin: <1.0EU per 1ug (determined by the LAL method)

other info2 :

Expression System: Prokaryotic expression. Tag: Two N-terminal Tags, His-tag and T7-tag. Organism Species: Equus caballus; Equine (Horse). Fragment: Thr23~Ser101. Usage: Reconstitute in sterile ddH2O.

ncbi gi num :

32130518

ncbi acc num :

NP_000474.2

ncbi gb acc num :

NM_000483.4

ncbi pathways :

Chylomicron-mediated Lipid Transport Pathway (1270006); HDL-mediated Lipid Transport Pathway (1270007); Lipid Digestion, Mobilization, And Transport Pathway (1270002); Lipoprotein Metabolism Pathway (1270005); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Retinoid Metabolism And Transport Pathway (1269624); Signal Transduction Pathway (1269379); Statin Pathway (198852); Visual Phototransduction Pathway (1269623)

ncbi summary :

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

uniprot summary :

APOC2: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B). It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Belongs to the apolipoprotein C2 family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: extracellular space; chylomicron; early endosome; extracellular region. Molecular Function: phospholipase binding; protein homodimerization activity; lipase inhibitor activity; lipid binding; phospholipase activator activity. Biological Process: phototransduction, visible light; positive regulation of fatty acid biosynthetic process; negative regulation of cholesterol transport; cholesterol efflux; lipoprotein metabolic process; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; negative regulation of catalytic activity; positive regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; retinoid metabolic process; negative regulation of lipid metabolic process; lipid catabolic process. Disease: Apolipoprotein C-ii Deficiency

size1 :

0.01 mg

price1 :

155 USD

size2 :

0.05 mg

price2 :

305

size3 :

0.1 mg

price3 :

470

size4 :

0.2 mg

price4 :

580

size5 :

0.5 mg

price5 :

1125

size6 :

1 mg

price6 :

1680

more info or order :

MyBioSource product webpage