Survivin, 1-142aa, Human, CaM-tag, Recombinant, E Coli | MyBioSource MBS203156 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Survivin, 1-142aa, Human, CaM-tag, Recombinant, E Coli

catalog :

MBS203156

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203156

products type :

Recombinant Protein

products full name :

Survivin, 1-142aa, Human, CaM-tag, Recombinant, E Coli

products short name :

Survivin

products name syn :

BIRC5; Baculoviral IAP repeat-containing 5; API4; EPR-1; Baculoviral IAP repeat-containing protein 5 isoform 1; Survivin; Baculoviral IAP repeat-containing protein 5 isoform 1 API4; Apoptosis Inhibitor 4; Apoptosis inhibitor survivin; Apoptosis inhibitor4; Baculoviral IAP repeat containing 5; Baculoviral IAP repeat containing protein 5; BIRC 5; EPR 1; IAP4; SVV; TIAP.

other names :

Baculoviral IAP repeat-containing 5; Baculoviral IAP repeat-containing protein 5; baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; apoptosis inhibitor survivin; survivin variant 3 alpha; baculoviral IAP repeat containing 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin

other gene names :

BIRC5; BIRC5; API4; EPR-1; API4; IAP4

uniprot entry name :

BIRC5_HUMAN

sequence length :

142

sequence :

MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAKG SHMGAPTLPP AWQPFLKDHR ISTFKNWPFL EGCACTPERM AEAGFIHCPT ENEPDLAQCF FCFKELEGWE PDDDPIEEHK KHSSGCAFLS VKKQFEELTL GEFLKLDRER AKNKIAKETN NKKKEFEETA KKVRRAIEQL AAMD

purity :

> 90% by SDS - PAGE

form :

Liquid in 20mM Tris pH 7.5, 0.1M NaCl.

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

Cancer

products description :

Survivin is a human gene that is part of the inhibitor of apoptosis family (IAP). The Survivin protein functions to inhibit caspase activation therefore leading to negative regulation of apoptosis or programmed cell death. Recombinant human Survivin fused to CaM-tag at N-terminus was expressed in E.coli and purified by conventional chromatography techniques.

products references :

Wolanin., et al. (2007). Postepy Biochem. 53(1):10-8. O'Driscoll L., et al. (2003) Curr Cancer Drug Targets. 3(2):131-52.

ncbi gi num :

21707887

ncbi acc num :

AAH34148

ncbi mol weight :

33 kDa (294 aa), confirmed by MALDI-TOF.

ncbi pathways :

Apoptosis Pathway (198797); Apoptosis Modulation And Signaling Pathway (198822); Aurora A Signaling Pathway (137925); Aurora B Signaling Pathway (138080); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518); FOXM1 Transcription Factor Network Pathway (137935); Hepatitis B Pathway (694606)

ncbi summary :

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

uniprot summary :

Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described. Protein type: Apoptosis. Chromosomal Location of Human Ortholog: 17q25. Cellular Component: centriole; nuclear chromosome; microtubule; cytoplasmic microtubule; spindle microtubule; cytoplasm; spindle; midbody; nucleus; cytosol; interphase microtubule organizing center; chromosome, pericentric region. Molecular Function: tubulin binding; identical protein binding; protein homodimerization activity; zinc ion binding; microtubule binding; metal ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; protein binding; enzyme binding; protein heterodimerization activity; chaperone binding; cofactor binding; cysteine protease inhibitor activity; Ran GTPase binding; cobalt ion binding. Biological Process: mitosis; transcription, DNA-dependent; spindle checkpoint; establishment of chromosome localization; protein ubiquitination; regulation of signal transduction; cytokinesis; negative regulation of caspase activity; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation; protein complex localization; cell division; positive regulation of cell proliferation; mitotic cell cycle; negative regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle; positive regulation of exit from mitosis; negative regulation of apoptosis

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage