mouse SCF, 26-189aa, mouse, Recombinant, E Coli | MyBioSource MBS203151 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

mouse SCF, 26-189aa, mouse, Recombinant, E Coli

catalog :

MBS203151

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203151

products type :

Recombinant Protein

products full name :

mouse SCF, 26-189aa, mouse, Recombinant, E Coli

products short name :

SCF

products name syn :

glycosylation inhibiting factor (GIF); GLIF; MMIF; SCF; Kitl; Clo; Con; contrasted; Gb; Kitlg; Mgf; SF; Sl; SLF; Steel; mouse SCF; Stem cell factor; Stem cell factor

other names :

kit ligand; Kit ligand; kit ligand; C-kit ligand; Steel factor; cloud gray; grizzle-belly; hematopoietic growth factor KL; mast cell growth factor; stem cell factor; kit ligand; Hematopoietic growth factor KL; Mast cell growth factor; MGF; Steel factor; Stem cell factor; SCF; c-Kit ligandSoluble KIT ligand; sKITLG

products gene name :

SCF

other gene names :

Kitl; Kitlg; Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted; Kitl; Mgf; Sl; Slf; MGF; SCF; sKITLG

uniprot entry name :

SCF_MOUSE

sequence length :

273

sequence :

MKEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA

purity :

> 95% by SDS - PAGE

form :

Liquid. In Phosphate buffer saline (pH 7.4) containing 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

Hormones & Cytokines

products description :

Stem Cell Factor (SCF) is a glycoprotein that plays a key role in hematopoiesis acting both as a positive and negative regulator, often in synergy with other cytokines. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. SCF stimulates the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It also mediates cellcell adhesion and acts synergistically with other cytokine. Recombinant mouse SCF was expressed in E. coli and purified by conventional column chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer

products references :

Zhang Z., et al. (2000). Proc. Natl. Acad. Sci. u.S.A. 97, 7732. Okada S, et al. (1992). Nippon Rinsho, 50, 1872.

ncbi gi num :

7305267

ncbi acc num :

NP_038626

ncbi gb acc num :

NM_013598.2

ncbi mol weight :

18 kDa (165 aa), confirmed by MALDI-TOF.

ncbi pathways :

Adaptive Immune System Pathway (1110669); Constitutive PI3K/AKT Signaling In Cancer Pathway (1111361); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); DAP12 Interactions Pathway (1110771); DAP12 Signaling Pathway (1110772); Disease Pathway (1111319); Downstream Signal Transduction Pathway (1110451); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (1110683); Downstream Signaling Of Activated FGFR Pathway (1110382)

uniprot summary :

SCF: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: extracellular space; cytoskeleton; membrane; cytoplasm; extracellular region; integral to membrane; plasma membrane. Molecular Function: protein binding; growth factor activity; cytokine activity; stem cell factor receptor binding. Biological Process: embryonic hemopoiesis; positive regulation of leukocyte migration; germ cell programmed cell death; germ cell development; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; ovarian follicle development; negative regulation of mast cell apoptosis; positive regulation of melanocyte differentiation; positive regulation of cell proliferation; positive regulation of myeloid leukocyte differentiation; positive regulation of Ras protein signal transduction; cell adhesion; neural crest cell migration; positive regulation of DNA replication; negative regulation of apoptosis

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage