product summary
Loading...
company name :
MyBioSource
product type :
protein
product name :
CNTF(Ciliary neurotrophic factor), 1-200aa, Human, His-tag, Recombinant, E Coli
catalog :
MBS203139
quantity :
0.1 mg
price :
375 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203139
products type :
Recombinant Protein
products full name :
CNTF(Ciliary neurotrophic factor), 1-200aa, Human, His-tag, Recombinant, E Coli
products short name :
CNTF
products name syn :
Ciliary neurotrophic factor; CNTF; Ciliary neurotrophic factor HCNTF.
other names :
ciliary neurotrophic factor; Ciliary neurotrophic factor; ciliary neurotrophic factor; ciliary neurotrophic factor
products gene name :
CNTF
other gene names :
CNTF; CNTF; HCNTF; CNTF
uniprot entry name :
CNTF_HUMAN
sequence length :
200
sequence :
MGSSHHHHHH SSGLVPRGSH MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM
purity :
> 95% by SDS - PAGE
form :
Liquid in 20mM Tris pH 8.0, 1mM DTT
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Neuroscience
products description :
CNTF (Ciliary neurotrophic factor) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. This protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. CNTF protein is structurally related to leukemia inhibitory factor (LIF), interleukin-6 (IL-6), interleukin-11 (IL-11) and oncostatin M (OSM). It is localized in the cell nucleus subsequent to receptor binding. Recombinant human CNTF, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Sendther M., et al. (1994), J Neurobiol. 25(11):1436-53. Robert F., et al. (2007), J. Biol. Chem. 282(46): 33421-33434.
ncbi gi num :
4758020
ncbi acc num :
NP_000605
ncbi gb acc num :
NM_000614.3
ncbi mol weight :
25kDa (220aa), confirmed by MALDI-TOF.
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Delta-Notch Signaling Pathway (198879); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)
ncbi summary :
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
uniprot summary :
CNTF: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. Belongs to the CNTF family. Chromosomal Location of Human Ortholog: 11q12.2. Cellular Component: extracellular space; cytoplasm. Molecular Function: interleukin-6 receptor binding; growth factor activity; ciliary neurotrophic factor receptor binding. Biological Process: negative regulation of photoreceptor cell differentiation; positive regulation of cell proliferation; neuron development; regulation of retinal cell programmed cell death; negative regulation of neuron apoptosis; signal transduction; muscle morphogenesis; positive regulation of tyrosine phosphorylation of Stat3 protein; growth
size1 :
0.1 mg
price1 :
375 USD
size2 :
0.5 mg
price2 :
925
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!