catalog number :
MBS203135
products type :
Recombinant Protein
products full name :
Rab5a, 1-215aa, Human, Recombinant, E Coli
products short name :
Rab5a
products name syn :
RAB5A; member RAS oncogene family; RAB5; Rab5a; RAB5A; member RAS oncogene family RAB 5; RAB 5A; RAB5A member RAS oncogene family; RAS associated protein RAB5A; Ras related protein Rab 5A.
other names :
ras-related protein Rab-5A isoform 1; Ras-related protein Rab-5A; ras-related protein Rab-5A; RAS-associated protein RAB5A; RAB5A, member RAS oncogene family; N/A
products gene name :
Rab5a
other gene names :
RAB5A; RAB5A; RAB5; RAB5
uniprot entry name :
RAB5A_HUMAN
sequence :
MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQ TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQR QASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKK LPKNEPQNPG ANSARGRGVD LTEPTQPTRN QCCSN
purity :
> 95% by SDS - PAGE
form :
Liquid in 20mM Tris pH8.0
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products categories :
Cancer
products description :
Rab5a is a member of RAS oncogene family. The small GTPase, Rab5a is a crucial regulatory component of the endocytic pathway. Activation of Rab5a is mediated by GDP-GTP exchange factors (GEFs) that generate the Rab5-GTP complex. Recombinant human Rab5a was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Tan BK, et al.(2007) J Clin Endocrinol Metab. 92(7):2590-7 . Yao-Borengasser A, et al.(2007)) J Clin Endocrinol Metab. 92(7):2430-2.
ncbi gb acc num :
NM_004162.4
ncbi mol weight :
23 kDa (215 aa), confirmed by MALDI-TOF.
ncbi pathways :
Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Amyotrophic Lateral Sclerosis (ALS) Pathway 920975!!Amyotrophic Lateral Sclerosis (ALS) Pathway 83099!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!EGFR1 Signaling Pathway 198782!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!ErbB1 Downstream Signaling Pathway 138057!!Factors Involved In Megakaryocyte Development And Platelet Production Pathway 187196