protein

Recombinant Defensin Alpha 6, Paneth Cell Specific (DEFa6)

MBS2031334

0.01 mg

140 USD

Recombinant Protein

Recombinant Defensin Alpha 6, Paneth Cell Specific (DEFa6)

[Defensin Alpha 6]

[defensin, alpha 6, Paneth cell-specific; Defensin-6; defensin-6; defensin, alpha 6, Paneth cell-specific; Defensin, alpha 6]

[DEFa6]

[DEFA6; DEFA6; DEF6; HD-6; DEF6]

DEF6_HUMAN

Host: E Coli. Source: Prokaryotic expression

100

The sequence of the target protein is listed below. AE PLQAEDDPLQ AKAYEADAQE QRGANDQDFA VSFAEDASSS LRALGSTRAF TCHCRRSCYS TEYSYGTCTV MGINHRFCC

>90%

Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

SDS-Page

Predicted isoelectric point: 5.9. Predicted Molecular Mass: 41.3kDa. Endotoxin: <1.0EU per 1ug (determined by the LAL method). Subcellular Location: Secreted.

Expression System: Prokaryotic expression. Tag: N-terminal His-Tag, GST-tag, S-tag. Organism Species: Homo sapiens (Human). Fragment: Ala19~Cys99. Usage: Reconstitute in sterile ddH2O.

50057840

AAT68876.1

10,975 Da

Alpha-defensins Pathway (1269266); Defensins Pathway (1269265); Immune System Pathway (1269170); Innate Immune System Pathway (1269203)

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]

defensin, alpha 6: Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1. Belongs to the alpha-defensin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: extracellular space; Golgi lumen; extracellular region. Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus

0.01 mg

140 USD

0.05 mg

260

0.1 mg

400

0.2 mg

495

0.5 mg

955

1 mg

1415