Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | MyBioSource MBS2031299 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1)

catalog :

MBS2031299

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2031299

products type :

Recombinant Protein

products full name :

Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1)

products short name :

[Latent Transforming Growth Factor Beta Binding Protein 1]

other names :

[latent-transforming growth factor beta-binding protein 1 isoform LTBP-1S; Latent-transforming growth factor beta-binding protein 1; latent-transforming growth factor beta-binding protein 1; latent transforming growth factor beta binding protein 1; Transforming growth factor beta-1-binding protein 1; TGF-beta1-BP-1]

products gene name :

[LTBP1]

other gene names :

[LTBP1; LTBP1; LTBP-1; TGF-beta1-BP-1]

uniprot entry name :

LTBP1_HUMAN

host :

E.coli

reactivity :

Human

sequence :

DADECLL FGQEICKNGF CLNTRPGYEC YCKQGTYYDP VKLQCFDMDE CQDPSSCIDG QCVNTEGSYN CFCTHPMVLD ASEKRCIRPA ESNEQIEETD VYQDLCWEHL SDEYVCSRPL VGKQTTYTEC CCLYGEAWGM QCALCPLKDS DDYAQLCNIP VTGRRQPYGR DALVDFSEQY TPEADPYFIQ DRFLNSFEEL QAEECGILNG CENGRCVRVQ EGYTCDCFDG YHLDTAKMTC VDVNECDELN NRMSLCKNAK CINTDGSYKC LCLPGYVPSD KPNYCTPLNTALNLEKDSDL E

purity :

>95%

form :

100mM NaHCO3, 500mM NaCl, pH8.3, containing 0.01% SKL, 5% Trehalose and Proclin300.

concentration :

Original Concentration: 200ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition

tested application :

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

SDS-Page

other info1 :

Source: Prokaryotic expression. Residues: Asp1424~Glu1721. Tags: N-terminal His Tag. Subcellular Location: n/a. Traits: Freeze-dried powder

other info2 :

Predicted isoelectric point: 4.2. Predicted Molecular Mass: 37.5kDa. Accurate Molecular Mass: 44kDa as determined by SDS-PAGE reducing conditions. Phenomenon explanation: The possible reasons that the actual band size differs from the predicted are as follows:. 1.Splice variants: Alternative splicing may create different sized proteins from the same gene. 2. Relative charge: The composition of amino acids may affects the charge of the protein. 3. Post-translational modification: Phosphorylation, glycosylation, methylation etc. 4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form. 5. Polymerization of the target protein: Dimerization, multimerization etc. Usage: Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

261337167

ncbi acc num :

NP_000618.3

ncbi gb acc num :

NM_000627.3

ncbi pathways :

Elastic Fibre Formation Pathway (1270251); Extracellular Matrix Organization Pathway (1270244); Integrated Pancreatic Cancer Pathway (711360); Molecules Associated With Elastic Fibres Pathway (1270252); TGF Beta Signaling Pathway (198810); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475)

ncbi summary :

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

LTBP1: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Belongs to the LTBP family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted; Chaperone. Chromosomal Location of Human Ortholog: 2p22-p21. Cellular Component: extracellular matrix; proteinaceous extracellular matrix; protein complex; extracellular region; microfibril. Molecular Function: transforming growth factor beta receptor activity; protein binding; transforming growth factor beta binding; microfibril binding; calcium ion binding. Biological Process: extracellular matrix organization and biogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

260

size3 :

0.1 mg

price3 :

400

size4 :

0.2 mg

price4 :

495

size5 :

0.5 mg

price5 :

955

size6 :

1 mg

price6 :

1415

more info or order :

MyBioSource product webpage