protein

Human PRMT1 isoform3, 1-353aa, Human, His-MBP tag, Recombinant, E Coli

MBS203118

0.1 mg

255 USD

Recombinant Protein

Human PRMT1 isoform3, 1-353aa, Human, His-MBP tag, Recombinant, E Coli

PRMT1 isoform3

ANM1; HCP1; HRMT1L2; IR1B4; protein arginine methyltransferase 1; HMT1 hnRNP methyltransferase-like 2 isoform 3; PRMT1; HMT1 hnRNP methyltransferase-like 2 isoform 3 ANM 1; HCP 1; Heterogeneous nuclear ribonucleoproteins methyltransferase like 2; HMT2; HRMT1 L2; HRMT1L 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like2; HMT 2; HMT1 (hnRNP methyltransferase S; cerevisiae) like 2; HMT1 hnRNP methyltransferase; HMT1 hnRNP methyltransferase like 2; HMT1 hnRNP methyltransferase like 2 (S; cerevisiae); Human mRNA for suppressor for yeast mutant; Human mRNA for suppressor for yeast mutant complete cds; Interferon receptor 1 bound protein 4; Interferon receptor 1 bound protein4; Interferon receptor 1bound protein 4; IR1 B4; IR1B 4; Mrmt 1; Mrmt1; PRMT 1; Protein arginine N methyltransferase 1; Protein arginine N methyltransferase1; S; cerevisiae like 2.

protein arginine N-methyltransferase 1 isoform 3; Protein arginine N-methyltransferase 1; protein arginine N-methyltransferase 1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; histone-arginine N-methyltransferase PRMT1; interferon receptor 1-bound protein 4; protein arginine methyltransferase 1; Histone-arginine N-methyltransferase PRMT1 (EC:2.1.1.125); Interferon receptor 1-bound protein 4

PRMT1 isoform3

PRMT1; PRMT1; ANM1; HCP1; IR1B4; HRMT1L2; HMT2; HRMT1L2; IR1B4

ANM1_HUMAN

353

MHHHHHHMKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFW AHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEI PALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNK HMNADTDYSI AEAAFNKGET AMTINGPWAW SNIDTSKVNY GVTVLPTFKG QPSKPFVGVL SAGINAASPN KELAKEFLEN YLLTDEGLEA VNKDKPLGAV ALKSYEEELA KDPRIAATME NAQKGEIMPN IPQMSAFWYA VRTAVINAAS GRQTVDEALK DAQTNSSSNN NNNNNNNNLG IEGRGSHMAA AEAANCIMEV SCGQAESSEK PNAEDMTSKD YYFDSYAHFG IHEEMLKDEV RTLTYRNSMF HNRHLFKDKV VLDVGSGTGI LCMFAAKAGA RKVIGIECSS ISDYAVKIVK ANKLDHVVTI IKGKVEEVEL PVEKVDIIIS EWMGYCLFYE SMLNTVLYAR DKWLAPDGLI FPDRATLYVT AIEDRQYKDY KIHWWENVYG FDMSCIKDVA IKEPLVDVVD PKQLVTNACL IKEVDIYTVK VEDLTFTSPF CLQVKRNDYV HALVAYFNIE FTRCHKRTGF STSPESPYTH WKQTVFYMED YLTVKTGEEI FGTIGMRPNA KNNRDLDFTI DLDFKGQLCE LSCSTDYRMR

> 90% by SDS - PAGE

Liquid in 40mM Tris pH 8.0, 100mM NaCl, 4mM MgCl2, 2mM DTT, 40% glycerol

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-MBP tag

Expression System: E Coli. Bioactivity: 10,000unit/ml. Assay: One unit will transfer 1pmol of methyl group to synthetic . peptide of histone H4 for 10 minutes at 37C.

Histone Related

Protein arginine N-methyltransferase 1(PRMT1) is a type I methyltransferase that transfers a methyl group from S-adenosylmethionine to guanidino nitrogens of arginine residues to form monomethylarginine and asymmetric dimethylarginine. Functions of type I arginine methylation in proteins may include regulation of transcription, modulation of the affinity of nucleic acid-binding proteins, regulation of interferon signaling pathways, and targeting of nuclear proteins. Recombinant human PRMT1, fused to His-MBP tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Goulet I., et al. (2007) J Biol Chem. 282(45):33009-21. Tang J., et al. (2000) J Biol Chem. 275(11):7723-30.

151301219

NP_938074

NM_198318.4

84 kDa (750 aa)

Chromatin Modifying Enzymes Pathway 1127682!!Chromatin Organization Pathway 1127681!!Direct P53 Effectors Pathway 137939!!Energy Metabolism Pathway 198907!!FoxO Signaling Pathway 921162!!Interferon Type I Pathway 920993!!RMTs Methylate Histone Arginines Pathway 1127687!!Tryptophan Metabolism Pathway 198850!!MRNA Processing Pathway 198843

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

0.1 mg

255 USD