catalog number :
MBS2031097
products type :
Recombinant Protein
products full name :
Recombinant Procollagen C Proteinase Enhancer 1 (PCPE1)
products short name :
[Procollagen C Proteinase Enhancer 1]
other names :
[procollagen C-endopeptidase enhancer 1; Procollagen C-endopeptidase enhancer 1; procollagen C-endopeptidase enhancer 1; procollagen C-endopeptidase enhancer; Procollagen COOH-terminal proteinase enhancer 1; PCPE-1; Procollagen C-proteinase enhancer 1; Type 1 procollagen C-proteinase enhancer protein; Type I procollagen COOH-terminal proteinase enhancer]
products gene name :
[PCPE1]
other gene names :
[PCOLCE; PCOLCE; PCPE; PCPE1; PCPE-1; PCPE1; PCPE-1; Procollagen C-proteinase enhancer 1]
uniprot entry name :
PCOC1_HUMAN
form :
20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose and Proclin300.
concentration :
Original Concentration: 200ug/mL
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)
image1 heading :
SDS-Page
other info1 :
Source: Prokaryotic expression. Residues: Gly38~Asp449. Tags: N-terminal His Tag. Subcellular Location: Secreted. Traits: Freeze-dried powder
other info2 :
Predicted isoelectric point: 7.5. Predicted Molecular Mass: 47.8kDa. Accurate Molecular Mass: 48kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
ncbi acc num :
NP_002584.2
ncbi gb acc num :
NM_002593.3
ncbi pathways :
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1270247); Collagen Biosynthesis And Modifying Enzymes Pathway (1270246); Collagen Formation Pathway (1270245); Crosslinking Of Collagen Fibrils Pathway (1270249); Extracellular Matrix Organization Pathway (1270244)
ncbi summary :
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
uniprot summary :
PCOLCE: Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. Protein type: Secreted; Secreted, signal peptide; Extracellular matrix. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: extracellular matrix; extracellular space. Molecular Function: heparin binding; collagen binding; protein binding; protease activator activity. Biological Process: multicellular organismal development; proteolysis