catalog number :
MBS2031048
products type :
Recombinant Protein
products full name :
Recombinant Sestrin 2 (SESN2)
products short name :
[Sestrin 2]
other names :
[sestrin 2; Sestrin-2; sestrin-2; sestrin 2; Hi95]
products gene name :
[SESN2]
other gene names :
[SESN2; SESN2; HI95; SES2; SEST2; SEST2]
uniprot entry name :
SESN2_HUMAN
sequence :
SRGPSAFIPV EEILREGAES LEQHLGLEAL MSSGRVDNLA VVMGLHPDYL SSFWRLHYLLLHTDGPLASS WRHYIAIMAA ARHQCSYLVG SHMTEFLQTG GDPEWLLGLHRAPEKLRKLS EVNKLLAHRP WLITKEHIQA LLKTGEHSWS LAELIQALVLLTHCHSLASF VFGCGILPEG DAEGSPASQA PSPPSEQGTP PSGDPLNNSGGFEAARDVEA LMERMRQLQE SLLRDEGASQ EEMENRFELE KSESLLVTPSADILEPSPHP DILCFVEDPA FGYEDFTRRG TQAPPTFRAQ DYTWEDHGYSLIQRLYPEGG QLLDEKFQVA CSLTYNTIAM HSGVDTSMLR RAIWNYIHCVFGIRYDDYDY GEVNQLLERN LKIYIKTVAC YPEKTTRRMY NLFWRHFRHSEKVHVNLLLL EARMQAALLY ALRAITRYMT
form :
20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.
concentration :
Original Concentration: 2006g/mL
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.)
image1 heading :
SDS-Page
other info1 :
Species: Mus musculus (Mouse). Source: Prokaryotic expression. Residues: Ser41~Thr480. Tags: N-terminal His Tag. Subcellular Location: Cytoplasm. Traits: Freeze-dried powder
other info2 :
Predicted isoelectric point: 5.6. Predicted Molecular Mass: 53.7kDa. Accurate Molecular Mass: 54kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
ncbi acc num :
EAX07703.1
ncbi pathways :
Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); TP53 Regulates Metabolic Genes Pathway (1269655); Transcriptional Regulation By TP53 Pathway (1269654); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)
ncbi summary :
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]
uniprot summary :
SESN2: Involved in the reduction of peroxiredoxins. Widely expressed. Belongs to the sestrin family. Protein type: Enzyme, misc. Chromosomal Location of Human Ortholog: 1p35.3. Cellular Component: cytoplasm; nucleus. Molecular Function: protein binding. Biological Process: fatty acid beta-oxidation; glucose import; response to glucose stimulus; protein kinase B signaling cascade; autophagy; mitochondrial DNA metabolic process; response to insulin stimulus