product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Interferon regulatory factor-3,1-112aa, Human, Recombinant, E Coli
catalog :
MBS203096
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203096
products type :
Recombinant Protein
products full name :
Interferon regulatory factor-3,1-112aa, Human, Recombinant, E Coli
products short name :
Interferon regulatory factor-3
products name syn :
IRF3; Interferon regulatory factor-3; IRF-3; Interferon regulatory factor 3; IRF 3.
other names :
interferon regulatory factor 3 isoform 1; Interferon regulatory factor 3; interferon regulatory factor 3; interferon regulatory factor 3; N/A
other gene names :
IRF3; IRF3; IRF-3
uniprot entry name :
IRF3_HUMAN
sequence length :
427
sequence :
MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NS
purity :
> 95% by SDS - PAGE
form :
Liquid. In Phosphate-buffered saline (pH 7.4)
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products categories :
Hormones & Cytokines
products description :
Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. Recombinant human IRF3 was expressed in E.coli and purified by using conventional chromatography techniques
products references :
Pietila TE et al., J Immunol. (2007) 178(1):253-61. DeFilippis VR et al., J Virol., (2006) 80(2):1032-7.
ncbi gi num :
4504725
ncbi acc num :
NP_001562
ncbi gb acc num :
NM_001571.5
ncbi mol weight :
13.0kDa (112aa), confirmed by MALDI-TOF.
ncbi pathways :
Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Antiviral Mechanism By IFN-stimulated Genes Pathway 530760!!Apoptosis Pathway 198797!!Cytokine Signaling In Immune System Pathway 366171!!Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!Epstein-Barr Virus Infection Pathway 585562!!Epstein-Barr Virus Infection Pathway 587115
ncbi summary :
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
size :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
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