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protein

Interleukin-8 Human, Recombinant, E Coli

MBS203086

0.1 mg

255 USD

MBS203086

Recombinant Protein

Interleukin-8 Human, Recombinant, E Coli

Interleukin-8

CXCL8; Neurophil chemotactic factor; NCF; Neutrophil activating protein; NAP; Monocyte derived neutrophil chemotactic factor; MDNCF; T-lymphocyte chemotactic factor; TCF; Granulocyte chemotactic protein; GCP; and Leukocyte adhension inhibitor; LAI; NAP 1; 3 10C; 310C; AMCF 1; AMCF1; b ENAP; Beta thromboglobulin like protein; CXC chemokine ligand 8; CXCL 8; Emoctakin; GCP 1; GCP1; Granulocyte chemotactic protein 1; IL 8; Inteleukin 8; Interleukin8; K 60; LECT; LuCT; Lymphocyte derived neutrophil activating factor; LYNAP; MDNCF; MDNCF a; MDNCF alpha; MONAP; Monocyte derived neutrophil activating protein; Monocyte derived neutrophil chemotactic factor; NAF; NAP1; Neutrophil activating factor; Neutrophil activating protein 1; Protein 3 10C; SCYB 8; SCYB8; T cell chemotactic factor; TSG 1; TSG1; il8

interleukin-8; Interleukin-8; interleukin-8; T-cell chemotactic factor; alveolar macrophage chemotactic factor I; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; emoctakin; granulocyte chemotactic protein 1; interleukin 8; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; tumor necrosis factor-induced gene 1; chemokine (C-X-C motif) ligand 8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factorCleaved into the following 7 chains:MDNCF-aAlternative name(s):GCP/IL-8 protein IV; IL8/NAP1 form I

CXCL8; CXCL8; IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; IL8; IL-8; GCP-1; MDNCF; MONAP; NAP-1; LYNAP; NAF

IL8_HUMAN

99

MAVLPRSAKE LRCQCIKTYS KPFHPKFIKE LRVIESGPHC ANTEIIVKLS DGRELCLDPK ENWVQRVVEK FLKRAENS

> 95% by SDS - PAGE

Liquid. In Phosphate buffer saline (pH 7.4)

1 mg/ml (determined by BCA assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

Hormones & Cytokines

Interleukin-8 (IL-8) is a chemokine, a member of the cytokine family that displays chemotactic activity for specific types of leukocytes. It is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8/IL-8 in response to a wide variety of pro-inflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. Recombinant human IL-8 was expressed in E. coli and purified by using conventional chromatography techniques.

Mukaida, N., et al.(1992)Microbiol. Immunol. 36, 773-789 . Larsen, C.G., et al. (1989). Science, 243, 1464-1466. Baldwin ET., et al. (1990). J Biol Chem. 265(12):6851-6853 .

10834978

NP_000575

NM_000584.3

9kDa (78aa), confirmed by MALDI-TOF.

ATF-2 Transcription Factor Network Pathway 138006!!ATF4 Activates Genes Pathway 530772!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Cellular Senescence Pathway 905991!!Cellular Responses To Stress Pathway 645258!!Chagas Disease (American Trypanosomiasis) Pathway 147809

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

0.1 mg

255 USD