product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Human Parathyroid Hormone Recombinant, E Coli
catalog :
MBS203075
quantity :
0.1 mg
price :
255 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203075
products type :
Recombinant Protein
products full name :
Human Parathyroid Hormone Recombinant, E Coli
products short name :
Parathyroid Hormone
products name syn :
PTH; Human Parathyroid Hormone; PTH; Parathyrin; Parathormone; Parathyroid hormone; hPTH; Parathormone
other names :
parathyroid hormone preproprotein; Parathyroid hormone; parathyroid hormone; parathormone; parathyrin; parathyroid hormone 1; prepro-PTH; preproparathyroid hormone; parathyroid hormone; Parathormone; Parathyrin
other gene names :
PTH; PTH; PTH1; PTH
uniprot entry name :
PTHY_HUMAN
sequence length :
115
sequence :
MSVSEIQLMH NLGKHLNSME RVEWLRKKLQ DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLT KAKSQ
purity :
> 95% by SDS - PAGE
form :
Liquid. In phosphate-buffered Saline(PBS), 2mM EDTA, pH7.4
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products categories :
Hormones & Cytokines
products description :
Human parathyroid hormone(hPTH) is an 84 amino acid residue peptide and one of the main regulators in maintenance of calcium homeostasis. It acts primarily on kidney and bone cells stimulating calcium back resorption or calcium mobilization, respectively. The whole mechanism is still under discussion, but low-dose hPTH triggers cyclic AMP-dependent protein kinase in some populations of bone cells bearing PTH receptors, which stimulates the proliferation of osteoblasts. Human parathyroid hormone(amino acids 1-84) was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques
products references :
Hodsman AB. et al. (2003) J. Clin. Endocrinol. Metab. 88(11), 5212-20. Wingender E., et al. (1989) J. Biol. Chem. 264(8),4367-73.
ncbi gi num :
4506267
ncbi acc num :
NP_000306
ncbi gb acc num :
NM_000315.2
ncbi mol weight :
9.55 kDa (85 aa), confirmed by MALDI-TOF.
ncbi pathways :
Class B/2 (Secretin Family Receptors) Pathway 106378!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!Endochondral Ossification Pathway 198812!!G Alpha (s) Signalling Events Pathway 119549!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!Metabolic Disorders Of Biological Oxidation Enzymes Pathway 1127637!!Osteoblast Signaling Pathway 198842!!Signal Transduction Pathway 477114
ncbi summary :
The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]
size :
0.1 mg
price :
255 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
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