protein

ubc7(ubiquitin Conjugating enzyme 7) Human Recombinant, expressed in E Coli

MBS203071

0.1 mg

255 USD

Recombinant Protein

ubc7(ubiquitin Conjugating enzyme 7) Human Recombinant, expressed in E Coli

ubc7

uBE2G1; uBE2G; ubc7 (ubiquitin Conjugating enzyme 7); EC 6.3.2.19; ubiquitin-protein ligase G1; ubiquitin carrier protein G1; E217K; uBC7; ubiquitin-conjugating enzyme E2 G1; ubiquitin-conjugating enzyme E2L 3 uBC 7; uBC7 homolog yeast; uBE 2G; ubiquitin conjugating enzyme E2 G1; ubiquitin conjugating enzyme E2G 1 (homologous to C; elegans uBC7); ubiquitin conjugating enzyme E2G 1 (uBC7 homolog C; elegans) antibody; ubiquitin conjugating enzyme E2G 1 (uBC7 homolog yeast); ubiquitin conjugating enzyme E2G 1; ubiquitin protein ligase G1

ubiquitin-conjugating enzyme E2 L3 isoform 1; Ubiquitin-conjugating enzyme E2 L3; ubiquitin-conjugating enzyme E2 L3; ubiquitin carrier protein L3; ubiquitin-conjugating enzyme E2-F1; ubiquitin-conjugating enzyme UBCH7; ubiquitin-protein ligase L3; ubiquitin-conjugating enzyme E2L 3; L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3

ubc7

UBE2L3; UBE2L3; E2-F1; L-UBC; UBCH7; UbcM4; UBCE7; UBCH7

UB2L3_HUMAN

154

MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD

> 95% by SDS - PAGE

Liquid. In 50 mM HEPES (pH7.5) 150 mM NaCl, 1mM DTT, 10% glycerol

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli

ubiquitination

Human ubquitin-conjugating enzyme 7(ubcH7) is a ubiquitin-conjugating enzyme (E2) mediating c-fos degradation, transcription factor NF-kappa B maturation, and human papilloma virus-mediated p53 and Myc protein degradation, in vitro. The ubiquitin-conjugating enzymes(E2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. The human uBE2L1-uBE2L4 gene could potentially encode different isoforms of the ubcH7. uBE2L3 gene, located at chromosome 22q11.2, is the only identical family member with introns and encodes a polypeptide sequence identical to that of ubcH7. ubcH7(154amino acid) was over-expressed in E.coli and purified by using conventional chromatography techniques.

Ardley HC., et al. (2000) Biochim Biophys Acta. 1491(1-3):57-64. Moynihan TP., et al. (1998) Genomics. 51(1):124-127. Nuber u., et al (1996) J Biol Chem. 271(5):2795-2800.

4507789

NP_003338

NM_003347.3

17.9 kDa (154 aa), confirmed by MALDI-TOF.

Adaptive Immune System Pathway 366160!!Alpha-synuclein Signaling Pathway 137913!!Antigen Processing: Ubiquitination Proteasome Degradation Pathway 366162!!BARD1 Signaling Events Pathway 137959!!Class I MHC Mediated Antigen Processing Presentation Pathway 366161!!Immune System Pathway 106386!!Parkin-Ubiquitin Proteasomal System Pathway 700638!!Parkinson's Disease Pathway 83098!!Parkinsons Disease Pathway 705377!!Ubiquitin Mediated Proteolysis Pathway 83056

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

0.1 mg

255 USD