protein

ubc9 (Human ubiquitin conjugating enzyme 9) Human, Recombinant, expressed in E Coli

MBS203069

0.1 mg

255 USD

Recombinant Protein

ubc9 (Human ubiquitin conjugating enzyme 9) Human, Recombinant, expressed in E Coli

ubc9

uBE2I; uBC9; uBCE9; ubc9; Human ubiquitin conjugating enzyme 9; EC 6.3.2; SuMO-protein ligase; ubiquitin-conjugating enzyme E2 I; ubiquitin-protein ligase I; ubiquitin carrier protein I; ubiquitin carrier protein 9; p18; SuMO-conjugating enzyme uBC9; ubiquitin-conjugating enzyme E2I C358B7.1; Homologous to yeast uBC9; p18; SuMO 1 conjugating enzyme; SuMO 1 protein ligase; SuMO conjugating enzyme uBC9; SuMO protein ligase; SuMO1 conjugating enzyme; SuMO1 protein ligase; uBC 9; uBC9 homolog; uBCE 9; uBE 2I; ubiquitin carrier protein; ubiquitin conjugating enzyme 9; ubiquitin conjugating enzyme E2I; ubiquitin conjugating enzyme ubcE2A; ubiquitin like protein SuMO 1 conjugating enzyme; ubiquitin like protein SuMO1 conjugating enzyme; ubiquitin protein ligase E2I; ubiquitin protein ligase I

SUMO-conjugating enzyme UBC9; SUMO-conjugating enzyme UBC9; SUMO-conjugating enzyme UBC9; SUMO-1-protein ligase; SUMO-protein ligase; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin conjugating enzyme 9; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9); ubiquitin-conjugating enzyme UbcE2A; ubiquitin-like protein SUMO-1 conjugating enzyme; ubiquitin-protein ligase E2I; ubiquitin-protein ligase I; ubiquitin-conjugating enzyme E2I; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18

ubc9

UBE2I; UBE2I; P18; UBC9; C358B7.1; UBC9; UBCE9

UBC9_HUMAN

158

MSGIALSRLA QERKAWRKDH PFGFVAVPTK NPDGTMNLMN WECAIPGKKG TPWEGGLFKL RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED KDWRPAITIK QILLGIQELL NEPNIQDPAQ AEAYTIYCQN RVEYEKRVRA QAKKFAPS

> 95% by SDS - PAGE

Liquid. In 50 mM HEPES (pH7.5) 150mM NaCl, 1mM DTT, 10%glycerol.

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

ubiquitination

Human ubc9 is homologous to ubiquitin-conjugating enzymes(E2s). However, instead of conjugating ubiquitin, it conjugates a ubiquitin homologue, small ubiquitin-like modifier 1(SuMO-1). And hubc9 retains striking structural and functional conservation with yeast ubc9. The ubiquitin-dependent protein degradation system has been recognized as a complete enzymatic pathway that is responsible for the selective degradation of abnormal and short-lived proteins. The conjugation of ubiquitin reuires the activities of ubiquitin-activating(E1) and -conjugating(E2) enzymes.

Tatham MH., et al (2003) Biochemistry. 42(11) 3168-3179. Donghai Lin, et al (2002) J. Biol. Chem. 277(24) 21740-21748. Wang ZY., et al. (1996) J. Biol. Chem. 271(40):24811-6.

4507785

NP_003336

NM_003345.4

18 kDa (158 aa), confirmed by MALDI-TOF.

Androgen Receptor Signaling Pathway 198806!!C-MYB Transcription Factor Network Pathway 138073!!Cell Cycle Pathway 530733!!Coregulation Of Androgen Receptor Activity Pathway 138085!!Meiosis Pathway 477133!!Meiotic Synapsis Pathway 477134!!Metabolism Of Proteins Pathway 106230!!MicroRNAs In Cancer Pathway 852705!!MicroRNAs In Cancer Pathway 852928!!NF-kappa B Signaling Pathway 634527

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

0.1 mg

255 USD