BIGH3, Fasciclin domain 4 (502-636aa) Human, Recombinant, E Coli | MyBioSource MBS203065 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

BIGH3, Fasciclin domain 4 (502-636aa) Human, Recombinant, E Coli

catalog :

MBS203065

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203065

products type :

Recombinant Protein

products full name :

BIGH3, Fasciclin domain 4 (502-636aa) Human, Recombinant, E Coli

products short name :

BIGH3

products name syn :

TGFBI; BIGH3; BIGH3; Fasciclin domain 4; Beta ig-h3; Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP; Transforming growth factor-beta-induced protein ig-h3; RGD containing collagen associated protein; Beta ig h3; AI747162; big h3; CSD3; Kerato epithelin; LCD1; MGC150270; RGD CAP; TGFBI transforming growth factor; beta induced; 68kDa; AI181842; Beta ig; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; EBMD; Transforming growth factor beta induced protein ig h3.

other names :

transforming growth factor-beta-induced protein ig-h3; Transforming growth factor-beta-induced protein ig-h3; transforming growth factor-beta-induced protein ig-h3; RGD-CAP; RGD-containing collagen-associated protein; beta ig-h3; kerato-epithelin; transforming growth factor, beta-induced, 68kD; transforming growth factor, beta-induced, 68kDa; Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP

products gene name :

BIGH3

other gene names :

TGFBI; TGFBI; CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; BIGH3; CDGG1; BIGH3; Beta ig-h3; RGD-CAP

uniprot entry name :

BGH3_HUMAN

sequence length :

683

sequence :

MGTVMDVLKG DNRFSMLVAA IQSAGLTETL NREGVYTVFA PTNEAFRALP PRERSRLLGD AKELANILKY HIGDEILVSG GIGALVRLKS LQGDKLEVSL KNNVVSVNKE PVAEPDIMAT NGVVHVITNV LQPPA

purity :

> 95% by SDS - PAGE

form :

Liquid. 20mM Tris pH8.0 Molecular Weight: 14.5 kDa (135 a.a, residues 502-636)

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

Cell Cycle

products description :

BIGH3, also known as TGFBI and betaig-h3, is an extracellular matrix protein induced by transforming growth factor(TGF)-beta 1. BIGH3 protein is involved in cell growth, cell differentiation, wound healing and cell adhesion. In addition, some missense mutations of BIGH3 were identified in families affected with human autosomal dominant corneal dystrophies. BIGH3 gene encodes for a 683 amino-acid protein containing an RGD motif and four internal repeated domains which have highly conserved sequences founded in several species (Fasciclin domain). Recombinant human BIGH3 protein (fourth FAS domain) was expressed in E. coli and purified by using conventional chromatography techniques.

products references :

Billings PC, et al. (2002). J Biol Chem. 277. 28003-28009. Munier FL. et al. (2002). Invest Ophthalmol Vis Sci. 43.949-954. Jung-Eun Kim, et al.(2000) J Biol Chem. 275. 30907-30915.

ncbi gi num :

4507467

ncbi acc num :

NP_000349

ncbi gb acc num :

NM_000358.2

ncbi mol weight :

14.5 kDa (135 aa), confirmed by MALDI-TOF.

ncbi pathways :

Amyloids Pathway (366238); Disease Pathway (530764)

ncbi summary :

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]

uniprot summary :

betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium. Protein type: Extracellular matrix; Secreted; Secreted, signal peptide; Cell adhesion. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; plasma membrane; extracellular region; basement membrane; trans-Golgi network. Molecular Function: collagen binding; integrin binding; protein binding; extracellular matrix binding. Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; negative regulation of cell adhesion; angiogenesis; cell adhesion. Disease: Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Lattice Type Iiia; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Avellino Type; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy, Groenouw Type I

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage