protein

CEBP-alpha, (bZIPregion, residues 270-358, His-tag, Human), E Coli

MBS203063

0.1 mg

255 USD

Recombinant Protein

CEBP-alpha, (bZIPregion, residues 270-358, His-tag, Human), E Coli

CEBP-alpha

CEBPA; CEBP-alpha bZIPregion residues 270-358; C/EBP alpha; CCAAT/enhancer-binding protein alpha; CAAT/enhancer binding protein a; Apoptotic cysteine protease; Apoptotic protease Mch 5; CAP4; Caspase 8 precursor; CCAAT Enhancer Binding Protein alpha; CEBP; CEBP A; CEBP alpha; FADD homologous ICE/CED 3 like protease; FADD like ICE; FLICE; ICE8; MACH; MCH5; MORT1 associated CED 3 homolog

CCAAT/enhancer-binding protein alpha isoform a; CCAAT/enhancer-binding protein alpha; CCAAT/enhancer-binding protein alpha; CCAAT/enhancer binding protein (C/EBP), alpha

CEBP-alpha

CEBPA; CEBPA; CEBP; C/EBP-alpha; C/EBP alpha

CEBPA_HUMAN

358

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGAG KAKKSVDKNS NEYRVRRERN NIAVRKSRDK AKQRNVETQQ KVLELTSDND RLRKRVEQLS RELDTLRGIF RQLPESSLVK AMGNCA

> 95% by SDS - PAGE

Liquid. In. 20mM Tris-HCl pH7.5, 0.1M NaCl, 5mM beta-Mercaptoethanol.

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Cell Cycle

CCAAT/enhancer binding protein(C/EBP) alpha is a family of transcription factors that all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP family consist of several related proteins, C/EBP alpha, beta, gamma,delta, that form homodimers and that form heterodimers with each other. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein; a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. C/EBPs differ significantly in their physiological functions and in their downstream target genes. For example, mice lacking C/EBP alpha die shortly after birth due to severe hypoglycemia and the absence of glycogen storage in liver, whereas knockout of C/EBPbeta causes defects in female reproduction The bZip region of CEBP-alpha (residues 270-358)was produced in E.coli and purified by ion-exchange chromatography and FPLC gel-filtration chromatography.

Subramanian,L., et.al.(2003) J.Biol.Chem. 278(11) 9134 - 9141. Gombart,A.F., et al (2002) Blood 99(4) 1332-1340.

28872794

NP_004355

NM_004364.4

14.5kDa (126aa), confirmed by MALDI-TOF.

Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adipogenesis Pathway 198832!!C-MYB Transcription Factor Network Pathway 138073!!Developmental Biology Pathway 477129!!E2F Transcription Factor Network Pathway 137934!!EGFR1 Signaling Pathway 198782!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911!!Non-alcoholic Fatty Liver Disease (NAFLD) Pathway 862188!!Non-alcoholic Fatty Liver Disease (NAFLD) Pathway 862314

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]

0.1 mg

255 USD