protein

Recombinant Defensin Alpha 4, Corticostatin (DEFa4)

MBS2030626

0.01 mg

140 USD

Recombinant Protein

Recombinant Defensin Alpha 4, Corticostatin (DEFa4)

[Defensin Alpha 4]

[defensin, alpha 4, corticostatin; Neutrophil defensin 4; neutrophil defensin 4; defensin, alpha 4, corticostatin; Defensin, alpha 4; HNP-4; HP-4]

[DEFa4]

[DEFA4; DEFA4; HP4; DEF4; HP-4; HNP-4; DEF4; HP-4]

DEF4_HUMAN

E.coli

97

QARGDEAP GQEQRGPEDQ DISISFAWDK SSALQVSGST RGMVCSCRLV FCRRTELRVG NCLIGGVSFT YCCTRVD

> 90%

100mMNaHC03, 500mMNaCI, pH8.3, containing 1 mM EOTA, 1mM OTT, 0.01 % SKL, 5% Trehalose and Proclin300.

Original Concentration: 200ug/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE; WB.

SDS-Page

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Gln23-Asp97. Tags: N-terminal His and GST Tag. Subcellular Location: Secreted

Traits: Freeze-dried powder. Predicted isoelectric point: 6.4. Predicted Molecular Mass: 38.2kDa. Accurate Molecular Mass: 38kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 100mM NaHC03, 500mM NaCI (pH8.3) to a concentration of 0.1-1.0 mg/mL. 00 not vortex.

50057841

AAT68877.1

Alpha-defensins Pathway (1269266); Defensins Pathway (1269265); Immune System Pathway (1269170); Innate Immune System Pathway (1269203)

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]

DEFA4: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. Belongs to the alpha-defensin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23. Cellular Component: extracellular space; Golgi lumen; extracellular region. Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus

0.01 mg

140 USD

0.05 mg

265

0.1 mg

405

0.2 mg

500

0.5 mg

970

1 mg

1435