KIR2DS4(p50 KIR, CD158), Human, Recombinant, E Coli | MyBioSource MBS203055 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

protein

product name :

KIR2DS4(p50 KIR, CD158), Human, Recombinant, E Coli

catalog :

MBS203055

quantity :

0.1 mg

price :

375 USD

product information

catalog number :

MBS203055

products type :

Recombinant Protein

products full name :

KIR2DS4(p50 KIR, CD158), Human, Recombinant, E Coli

products short name :

KIR2DS4

products name syn :

KIR2DS4; CD158I; KKA3; NKAT8; KIR2DS4; p50 KIR; CD158; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clone CL-39; p58 NK receptor; CL-17; CD158 antigen-like family member I; CD15; Killer cell immunoglobulin-like receptor 2DS4; Killer cell immunoglobulin-like receptor 2DS4; CD158 antigen like family member I; CD158i antigen; CL 17; CL 39; CL17; CL39; Killer cell immunoglobulin like receptor two domains short cytoplasmic tail 4; Killer inhibitory receptor 4 1 2; KIR antigen 2DS4; KIR1D; KIR412; MGC120019; MGC125315; MGC125317; MHC class I NK cell receptor; Natural killer associated transcript 8; Natural killer cell inhibitory receptor; NKAT 8; P58 natural killer cell receptor clone CL 39; p58 NK receptor

other names :

killer cell immunoglobulin-like receptor 2DS4 isoform 1; Killer cell immunoglobulin-like receptor 2DS4; killer cell immunoglobulin-like receptor 2DS4; CD158 antigen-like family member I; KIR antigen 2DS4; MHC class I NK cell receptor; P58 natural killer cell receptor clones CL-39/CL-17; killer Ig receptor; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1; killer inhibitory receptor 4-1-2; natural killer cell inhibitory receptor; natural killer-associated transcript 8; p58 NK receptor CL-39/CL-17; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4; CD158 antigen-like family member I; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor CL-39/CL-17; CD_antigen: CD158i

products gene name :

KIR2DS4

other gene names :

KIR2DS4; KIR2DS4; KKA3; KIR1D; NKAT8; CD158I; KIR412; NKAT-8; KIR2DS1; CD158I; KKA3; NKAT8; NKAT-8; p58 NK receptor CL-39/CL-17

uniprot entry name :

KI2S4_HUMAN

sequence length :

304

sequence :

MEGVHRKPSF LALPGHLVKS EETVILQCWS DVMFEHFLLH REGKFNNTLH LIGEHHDGVS KANFSIGPMM PVLAGTYRCY GSVPHSPYQL SAPSDPLDMV IIGLYEKPSL SAQPGPTVQA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAVRSINGTF QADFPLGPAT HGGTYRCFGS FRDAPYEWSN SSDPLLVSVT GN

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20 mM Tris-HCl buffer(pH7.5).

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

NK Cell Receptors

products description :

An activating Killer Cell Ig-like Receptor(KIR, previously called p50 KIR, p50.3, cl39, or KAR-K1), which may recognize class I MHC molecules. The protein coding region of the extracellular domain of KIR2DS4(amino acids 1-202) was cloned into an E. coli expression vector. The extracellular domain of KIR2DS4 was overexpressed as insoluble protein aggregates(inclusion bodies). The recombinant KIR2DS4 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.

products references :

Steffens u., et al. (1998) Tissue Antigens 51, 398-413. Wagtmann N., et al. (1995) Immunity. 2, 439-449.

ncbi gi num :

116517309

ncbi acc num :

NP_036446

ncbi gb acc num :

NM_012314.5

ncbi mol weight :

22.2 kDa (202 aa), confirmed by MALDI-TOF.

ncbi pathways :

Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!DAP12 Interactions Pathway 685549!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Natural Killer Cell Mediated Cytotoxicity Pathway 83079!!Natural Killer Cell Mediated Cytotoxicity Pathway 490

ncbi summary :

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

375 USD