protein

KIR2DL3 (23-223aa), Human, Recombinant, E Coli

MBS203054

0.1 mg

375 USD

Recombinant Protein

KIR2DL3 (23-223aa), Human, Recombinant, E Coli

KIR2DL3

KIR2DL3; CD158B2; KIRCL23; NKAT2; KIR2DL3 (p58 KIR; CD158); MHC class I NK cell receptor; Natural killer-associated transcript 2; NKAT-2; NKAT2a; NKAT2b; p58 natural killer cell receptor clone CL-6; p58 NK receptor; p58.2 MHC class-I-specific NK re; Killer cell immunoglobulin-like receptor 2DL3; Killer cell immunoglobulin-like receptor 2DL3 CD158b; GL183; Killer Cell Immunoglobulin Like Receptor 2DL3; Killer inhibitory receptor CL2 3; KIR023GB; MHC Class I NK Cell Receptor; Natural Killer Associated Transcript 2; p58; p58 Natural Killer Cell Receptor Clone CL6; p58.2 MHC Class I Specific NK Receptor

killer cell immunoglobulin-like receptor 2DL3; Killer cell immunoglobulin-like receptor 2DL3; killer cell immunoglobulin-like receptor 2DL3; CD158 antigen-like family member B2; MHC class I NK cell receptor; NK-receptor; NKAT-2; killer Ig-like inhibitory receptor; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; killer inhibitory receptor cl 2-3; natural killer associated transcript 2; natural killer cell inhibitory receptor KIR2DL3; natural killer-associated transcript 2; p58 NK receptor CL-6; p58 natural killer cell receptor clone CL-6; p58.2 MHC class-I specific NK receptor; p58.2 MHC class-I-specific NK receptor; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT2a; NKAT2b; Natural killer-associated transcript 2; NKAT-2; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I-specific NK receptor; CD_antigen: CD158b2

KIR2DL3

KIR2DL3; KIR2DL3; p58; NKAT; GL183; NKAT2; CD158b; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB; CD158B2; KIRCL23; NKAT2; NKAT-2; p58 NK receptor CL-6

KI2L3_HUMAN

341

MEGVHRKPSL LAHPGPLVKS EETVILQCWS DVRFQHFLLH REGKFKDTLH LIGEHHDGIS KANFSIGPMM QDLAGTYRCY GSVTHSPYQL SAPSDPLDIV ITGLYEKPSL SAQPGPTVLA GESVTLSCSS RSSYDMYHLS REGEAHERRF SAGPKVNGTF QADFPLGPAT HGGTYRCFGS FRDSPYEWSN SSDPLLVSVT GN

> 95% by SDS - PAGE

Liquid. In 20 mM Tris-HCl buffer(pH7.5).

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli

NK Cell Receptors

An inhibitory Killer Cell Ig-like Receptor(KIR, previously called p58 KIR, cl-6, NKAT2 or KIR-K7), which recognizes class I MHC molecules(HLA-Cw1, -Cw3, -Cw7, and Cw8). The protein coding region of the extracellular domain of KIR2DL3 (22-223aa) was cloned into an E. coli expression vector. The extracellular domain of KIR2DL3 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.

Steffens, u. et al. (1998) Tissue Antigens 51, 398-413. Wagtmann, N. R., et al. (1995) Immunity 2, 439-449. Colonna, M. et al. (1995) Science 268, 405-408. Kim, J. et al. (1997) J. Immunol. 159, 3875-3882.

71143139

NP_056952.2

NM_015868.2

22.2kDa (202aa), confirmed by MALDI-TOF.

Adaptive Immune System Pathway 366160!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!DAP12 Interactions Pathway 685549!!Graft-versus-host Disease Pathway 83124!!Graft-versus-host Disease Pathway 536!!Immune System Pathway 106386!!Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway 106413!!Innate Immune System Pathway 106387!!Natural Killer Cell Mediated Cytotoxicity Pathway 83079

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

0.1 mg

375 USD