KIR2DL1(p58 KIR, CD158), Human, Recombinant, E Coli | MyBioSource MBS203053 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

protein

product name :

KIR2DL1(p58 KIR, CD158), Human, Recombinant, E Coli

catalog :

MBS203053

quantity :

0.1 mg

price :

375 USD

product information

catalog number :

MBS203053

products type :

Recombinant Protein

products full name :

KIR2DL1(p58 KIR, CD158), Human, Recombinant, E Coli

products short name :

KIR2DL1

products name syn :

KIR2DL1; CD158A; NKAT1; KIR2DL1 (p58 KIR; CD158); MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor; p58.1 MHC class-I-specific NK receptor; Killer cell immunoglobulin-like receptor 2DL1; Killer cell immunoglobulin-like receptor 2DL1 Killer cell immunoglobulin like receptor 2DL1; MHC class I NK cell receptor; Natural killer associated transcript 1; NKAT 1; p58 NK receptor; p58.1 MHC class I specific NK receptor

other names :

killer cell immunoglobulin-like receptor 2DL1; Killer cell immunoglobulin-like receptor 2DL1; killer cell immunoglobulin-like receptor 2DL1; CD158 antigen-like family member A; MHC class I NK cell receptor; killer Ig receptor; killer inhibitory receptor 2-2-1; natural killer-associated transcript 1; p58 NK cell inhibitory receptor NKR-K6; p58 NK receptor CL-42/47.11; p58 killer cell inhibitory receptor KIR-K64; p58 natural killer cell receptor clones CL-42/47.11; p58.1 MHC class-I-specific NK receptor; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; CD158 antigen-like family member A; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor CL-42/47.11; p58.1 MHC class-I-specific NK receptor; CD_antigen: CD158a

products gene name :

KIR2DL1

other gene names :

KIR2DL1; KIR2DL1; NKAT; NKAT1; p58.1; CD158A; KIR221; NKAT-1; KIR-K64; CD158A; NKAT1; NKAT-1; p58 NK receptor CL-42/47.11

uniprot entry name :

KI2L1_HUMAN

sequence length :

348

sequence :

MEGVHRKPSL LAHPGRLVKS EETVILQCWS DVMFEHFLLH REGMFNDTLR LIGEHHDGVS KANFSISRMT QDLAGTYRCY GSVTHSPYQV SAPSDPLDIV IIGLYEKPSL SAQLGPTVLA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAGPKVNGTF QADFPLGPAT HGGTYRCFGS FHDSPYEWSK SSDPLLVSVT GN

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20 mM Tris-HCl buffer(pH7.5).

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

NK Cell Receptors

products description :

An inhibitory Keller Cell Ig-like Receptor(KIR, previously called p58 KIR, p58.1, cl-42, NKAT1, or KIR-K6), which recognizes class I MHC molecules(HLA-Cw2, -Cw4, -Cw5, and Cw6). The protein coding region of the extracellular domain of KIR2DL1(amino acids 1-202) was cloned into an E. coli expression vector. The extracellular domain of KIR2DL1 was overexpressed as insoluble protein aggregates(inclusion bodies). The recombinant KIR2DL1 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.

products references :

Steffens, u. et al. (1998) Tissue Antigens 51, 398-413. Wagtmann, N.R., et al. (1995) Immunity 2, 439-449. Colonna, M. et al. (1995) Science 269, 405-408; . Kim, J. et al. (1997) J. Immunol. 159, 3875-3882.

ncbi gi num :

110611923

ncbi acc num :

NP_055033

ncbi gb acc num :

NM_014218.2

ncbi mol weight :

22.2kDa (202aa), confirmed by MALDI-TOF.

ncbi pathways :

Adaptive Immune System Pathway 366160!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Graft-versus-host Disease Pathway 83124!!Graft-versus-host Disease Pathway 536!!Immune System Pathway 106386!!Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway 106413!!Natural Killer Cell Mediated Cytotoxicity Pathway 83079!!Natural Killer Cell Mediated Cytotoxicity Pathway 490

ncbi summary :

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

375 USD