14-3-3 tau, 1-245aa, Human, Recombinant, E Coli | MyBioSource MBS203052 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

14-3-3 tau, 1-245aa, Human, Recombinant, E Coli

catalog :

MBS203052

quantity :

0.1 mg

price :

375 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203052

products type :

Recombinant Protein

products full name :

14-3-3 tau, 1-245aa, Human, Recombinant, E Coli

products short name :

14-3-3 tau

products name syn :

YWHAQ; 1C5; HS1; 14-3-3 tau; Tyrosine 3/tryptophan 5 -monooxygenase activation protein; theta polypeptide; tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein; theta polypeptide 14 3 3 protein T cell; 14 3 3 protein tau; 14 3 3 protein theta; 14 3 3 tau; 14 3 3 theta; KCIP1; Protein HS1; Protein kinase C inhibitor protein 1; tyr3/trp5 monooxygenase activation protein; theta; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein; theta polypeptide.

other names :

14-3-3 protein theta; 14-3-3 protein theta; 14-3-3 protein theta; 14-3-3 protein T-cell; 14-3-3 protein tau; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta; 14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1

products gene name :

14-3-3 tau

other gene names :

YWHAQ; YWHAQ; 1C5; HS1; 14-3-3

uniprot entry name :

1433T_HUMAN

sequence length :

245

sequence :

MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA EGAEN

purity :

> 95% by SDS - PAGE

form :

Liquid in Phosphate buffered saline (pH7.4), 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

Signal Transduction

products description :

The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon,sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 tau, a subtype of the 14-3-3 family of proteins, was found in T Cells, brain and testes. This 14-3-3 tau is upregulated in patients with amyotrophic lateral sclerosis. Recombinant human YWHAQ was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Liu YC, et al. (1996) J Biol Chem; 271: 14591-5. Xiao B, et al. (1995) Nature, 376; 188-191.

ncbi gi num :

5803227

ncbi acc num :

NP_006817

ncbi gb acc num :

NM_006826.3

ncbi mol weight :

27 kDa (245 aa), confirmed by MALDI-TOF.

ncbi pathways :

Activation Of BAD And Translocation To Mitochondria Pathway (105659); Activation Of BH3-only Proteins Pathway (105658); Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Calcium Regulation In The Cardiac Cell Pathway (198906); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Class I PI3K Signaling Events Mediated By Akt Pathway (138020); Epstein-Barr Virus Infection Pathway (585562)

ncbi summary :

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

uniprot summary :

14-3-3 theta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 2p25.1. Cellular Component: focal adhesion; cytoplasmic vesicle membrane; membrane; cytoplasm; cytosol. Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding. Biological Process: substantia nigra development; apoptosis; small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; protein targeting

size1 :

0.1 mg

price1 :

375 USD

size2 :

0.5 mg

price2 :

925

more info or order :

MyBioSource product webpage