protein

RAC1, Human, Recombinant, E Coli

MBS203044

0.1 mg

255 USD

Recombinant Protein

RAC1, Human, Recombinant, E Coli

RAC1

RAC1; RAC1; p21-Rac1; Ras-like protein TC25; Cell migration-inducing gene 5 protein; Ras-related C3 botulinum toxin substrate 1; Ras-related C3 botulinum toxin substrate 1 isoform Rac1 MGC111543; MIG 5; MIG5; Migration inducing gene 5; Migration inducing protein 5; p21 Rac1; Rac 1; Ras like protein TC25; Ras related C3 botulinum toxin substrate 1; Rho family small GTP binding protein Rac1; TC 25

ras-related C3 botulinum toxin substrate 1 isoform Rac1; Ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1; cell migration-inducing gene 5 protein; ras-like protein TC25; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1

RAC1

RAC1; RAC1; MIG5; Rac-1; TC-25; p21-Rac1; TC25

RAC1_HUMAN

192

MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKCL LL

> 95% by SDS - PAGE

Liquid. In 20mM Tris-HCl pH7.5, 2mM EDTA, 1mMDTT

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli

Signal Transduction

Rac1, belonging to the Rho small GTPase family, regulates the actin cytoskeleton but also other cellular processes. RAC1 have been shown to be involved in the regulation of cell-cell adhesion. Recombinant RAC1 was expressed in E.coli and purified by using conventional chromatography techniques.

Chrostek A., et al. (2006) Mol Cell Biol. 26, 6957-70. Sun CX., (2004) Blood. 104(12):3758-65.

9845511

NP_008839

NM_006908.4

21.4 kDa (192 aa), confirmed by MALDI-TOF.

AGE/RAGE Pathway (698754); Activation Of Rac Pathway (119530); Adaptive Immune System Pathway (366160); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Alpha6-Beta4 Integrin Signaling Pathway (198807); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Androgen Receptor Signaling Pathway (198806)

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

RAC1: a plasma membrane-associated member of the Rho-GTPase family. Plays a key role in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the downstream signal transduction pathway. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Two alternatively spliced isoforms have been described. Protein type: G protein, monomeric, Rho; Motility/polarity/chemotaxis; G protein; G protein, monomeric. Chromosomal Location of Human Ortholog: 7p22. Cellular Component: Golgi membrane; extrinsic to plasma membrane; focal adhesion; membrane; lamellipodium; cytoplasm; melanosome; plasma membrane; actin filament; trans-Golgi network; cytosol; phagocytic cup. Molecular Function: GTPase activity; protein binding; enzyme binding; GTP binding; GTP-dependent protein binding; thioesterase binding; Rho GDP-dissociation inhibitor binding; protein kinase binding; Rab GTPase binding. Biological Process: axon guidance; viral reproduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; metabolic process; cell-matrix adhesion; cell motility involved in cell locomotion; regulation of cell migration; localization within membrane; positive regulation of focal adhesion formation; actin filament polymerization; small GTPase mediated signal transduction; positive regulation of stress fiber formation; ephrin receptor signaling pathway; response to wounding; inflammatory response; cell adhesion; bone resorption; regulation of hydrogen peroxide metabolic process; lamellipodium biogenesis; intercellular junction assembly and maintenance; embryonic olfactory bulb interneuron precursor migration; platelet activation; anatomical structure morphogenesis; Wnt receptor signaling pathway, planar cell polarity pathway; mast cell chemotaxis; dendrite morphogenesis; positive regulation of phosphoinositide 3-kinase activity; positive regulation of Rho protein signal transduction; engulfment of apoptotic cell; regulation of defense response to virus by virus; G-protein coupled receptor protein signaling pathway; cell proliferation; negative regulation of interleukin-23 production; hyperosmotic response; positive regulation of actin filament polymerization; organization of an anatomical structure; T cell costimulation; auditory receptor cell morphogenesis; ruffle organization and biogenesis; innate immune response; negative regulation of receptor-mediated endocytosis; cerebral cortex radially oriented cell migration; positive regulation of protein amino acid phosphorylation; cell motility; blood coagulation; vascular endothelial growth factor receptor signaling pathway; actin cytoskeleton organization and biogenesis; positive regulation of DNA replication

0.1 mg

255 USD

0.5 mg

535