protein

Recombinant Transferrin Receptor 2 (TFR2)

MBS2030348

0.01 mg

130 USD

Recombinant Protein

Recombinant Transferrin Receptor 2 (TFR2)

[Transferrin Receptor 2]

[transferrin receptor protein 2 isoform 2; Transferrin receptor protein 2; transferrin receptor protein 2; transferrin receptor 2]

[TFR2]

[TFR2; TFR2; HFE3; TFRC2; TfR2]

TFR2_HUMAN

E Coli

> 97%

Original Concentration: 200 Ug/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control, Immunogen, SDS-PAGE, Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

SDS-Page

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Tyr493~Gln784. Tags: N-terminal His Tag. Traits: Freeze-dried powder. Buffer formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 5% Trehalose.

Predicted isoelectric point: 6.4. Predicted Molecular Mass: 36.8 kDa. Accurate Molecular Mass: 37kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150 mM NaCI(pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

332309171

NP_001193784.1

NM_001206855.1

Iron Metabolism In Placenta Pathway (672461)

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: integral to plasma membrane; cytoplasm. Molecular Function: transferrin receptor activity. Biological Process: receptor-mediated endocytosis; cellular iron ion homeostasis; iron ion transport. Disease: Hemochromatosis, Type 3

0.01 mg

130 USD

0.05 mg

225

0.1 mg

340

0.2 mg

415

0.5 mg

800

1 mg

1180