protein

HSP 90 (amino acids 1-732), Human, Recombinant, His-tag, E Coli

MBS203032

0.1 mg

375 USD

Recombinant Protein

HSP 90 (amino acids 1-732), Human, Recombinant, His-tag, E Coli

HSP 90

HSP 86; Renal carcinoma antigen NY-REN-38; HSPC1; HSPCA; Heat shock protein 90-alpha Renal carcinoma antigen NY REN 38; D6S182; FLJ26984; FLJ31884; Heat shock 90kDa protein 1 alpha; heat shock protein 90kDa alpha (cytosolic); class A member 2; HSP84; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90AA1; HSP90ALPHA; HSP90N; HSPCAL3; HSPCB; HSPN; LAP2; Lipopolysaccharide associated protein2; LPS associated protein 2; NY REN 38 antigen; hsp90; Heat shock protein HSP 90-alpha

heat shock protein HSP 90-alpha isoform 2; Heat shock protein HSP 90-alpha; heat shock protein HSP 90-alpha; HSP 86; LPS-associated protein 2; epididymis luminal secretory protein 52; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; lipopolysaccharide-associated protein 2; renal carcinoma antigen NY-REN-38; heat shock protein 90kDa alpha (cytosolic), class A member 1; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38

HSP 90

HSP90AA1; HSP90AA1; EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4; HSP90A; HSPC1; HSPCA; HSP 86; HSP86; LAP-2; LPS-associated protein 2

HS90A_HUMAN

732

MGSSHHHHHH SSGLVPRGSH MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIR YESLTDPSKL DSGKELHINL IPNKQDRTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVGFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGEPM GRGTKVILHL KEDQTEYLEE RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAEEKED KEEEKEKEEK ESEDKPEIED VGSDEEEEKK DGDKKKKKKI KEKYIDQEEL NKTKPIWTRN PDDITNEEYG EFYKSLTNDW EDHLAVKHFS VEGQLEFRAL LFVPRRAPFD LFENRKKKNN IKLYVRRVFI MDNCEELIPE YLNFIRGVVD SEDLPLNISR EMLQQSKILK VIRKNLVKKC LELFTELAED KENYKKFYEQ FSKNIKLGIH EDSQNRKKLS ELLRYYTSAS GDEMVSLKDY CTRMKENQKH IYYITGETKD QVANSAFVER LRKHGLEVIY MIEPIDEYCV QQLKEFEGKT LVSVTKEGLE LPEDEEEKKK QEEKKTKFEN LCKIMKDILE KKVEKVVVSN RLVTSPCCIV TSTYGWTANM ERIMKAQALR DNSTMGYMAA KKHLEINPDH SIIETLRQKA EADKNDKSVK DLVILLYETA LSSGFSLEDPQTHANRIYR MIKLGLGIDE DDPTADDTSA AVTEEMPPLE GDDDTSRMEE VD

> 90% by SDS - PAGE

Liquid. 20 mM Tris-HCl, pH 7.4, containing 100 mM NaCl

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Heat Shock Proteins

HSP 90 is a human heat shock protein. In response to adverse change in their environment, cell from all organisms increase the expression of a class of proteins referred to as heat shock or stress protein. The Hsp90, a highly conserved stress-induced protein, is abundantly expressed in most tissues under nonstress conditions and is required for eukaryotic cell viability. Hsp90 is primarily a cytoplasmic protein and its function remains unknown. It exists in a dimeric form and has been observed to bind to several other cellular proteins such as retro-virus kinases, steroid receptor, heme-regulated protein kinase, actin and tubulin. Recombinant human Hsp90 alpha, fused to His-tag at N-terminus, was cloned into an E. coli expression vector and was purified to apparent homogeneity by using conventional column chromatography techniques.

Lai, B-T., et al.(1984) Molecular & Cellular Biol. 4: 2802-2810. Pritchard, K. A., et al.(2001) J. Biol. Chem. 276:17621-17624. Miyamoto, A., et al. (2002) Nature 416:865-869.

154146191

NP_005339

NM_005348.3

86.8kDa (752aa), confirmed by MALDI-TOF.

AhR Pathway (755436); Anchoring Of The Basal Body To The Plasma Membrane Pathway (1127503); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Assembly Of The Primary Cilium Pathway (1127502); Attenuation Phase Pathway (1127556); Axon Guidance Pathway (105688); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765)

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

HSP90A: a molecular chaperone of the heat shock protein 90 family. Has ATPase activity. Known to interact with a wide variety of proteins including steroid hormone receptors, neuropeptide Y, FKBP51/54, and FKBP52. G protein-coupled receptor kinases are stabilized by interacting with HSP 90. Hsp70 and Hsp90 promote tau solubility and tau binding to microtubules, reducing insoluble tau phosphorylation of tau. Protein type: Chaperone; Heat shock protein. Chromosomal Location of Human Ortholog: 14q32.33. Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; extracellular region; plasma membrane; melanosome; nucleus; cytosol. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; TPR domain binding; nitric-oxide synthase regulator activity; ATPase activity; unfolded protein binding; nucleotide binding; ATP binding. Biological Process: receptor-mediated endocytosis; axon guidance; positive regulation of nitric oxide biosynthetic process; organelle organization and biogenesis; signal transduction; nitric oxide metabolic process; protein import into mitochondrial outer membrane; response to unfolded protein; mitochondrial transport; innate immune response; protein refolding; mitotic cell cycle; regulation of nitric-oxide synthase activity; vascular endothelial growth factor receptor signaling pathway; chaperone-mediated protein complex assembly; G2/M transition of mitotic cell cycle

0.1 mg

375 USD

0.5 mg

925