Syntaxin 1A, 1-226aa, Human, Recombinant, E Coli | MyBioSource MBS203020 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Syntaxin 1A, 1-226aa, Human, Recombinant, E Coli

catalog :

MBS203020

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203020

products type :

Recombinant Protein

products full name :

Syntaxin 1A, 1-226aa, Human, Recombinant, E Coli

products short name :

Syntaxin 1A

products name syn :

STX1A; STX1; Syntaxin 1A; Neuron-specific antigen HPC-1; Syntaxin-1A; HPC 1; Neuron specific antigen HPC1; STX1; Syntaxin 1A brain.

other names :

syntaxin-1A isoform 1; Syntaxin-1A; syntaxin-1A; neuron-specific antigen HPC-1; syntaxin 1A (brain); Neuron-specific antigen HPC-1

other gene names :

STX1A; STX1A; STX1; HPC-1; P35-1; SYN1A; STX1

uniprot entry name :

STX1A_HUMAN

sequence length :

288

sequence :

MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQ

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20mM Tris-HCI buffer (pH 7.5) containing 1mM DTT, 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

Neuroscience

products description :

Syntaxin is membrane integrated Q-SNARE protein participating in exocytosis. Syntaxin is composed of an N-terminal regulatory domain(Habc), a SNARE domain(known as H3), and a single C-terminal transmembrane domain. The SNARE(H3) domain binds to both synaptobrevin and SNAP-25 forming the core SNARE complex. Recombinant syntaxin 1A protein(1-226aa) contains N-terminal domain(Habc) and t_SNARE domain(H3 domain) and this protein was overexpressed in E.coli and purified by using the conventional column chromatography techniques.

products references :

Han X., et al. (2004) Science. 304:289-292. Woodbury DJ. et al. (2000) Cell Biology International. 24(11):809-818.

ncbi gi num :

4759182

ncbi acc num :

NP_004594

ncbi gb acc num :

NM_004603.3

ncbi mol weight :

26.1 kDa (226 aa), confirmed by MALDI-TOF.

ncbi pathways :

Acetylcholine Neurotransmitter Release Cycle Pathway (106525); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Disease Pathway (530764); Dopamine Neurotransmitter Release Cycle Pathway (106523); Effects Of Botulinum Toxin Pathway (138028); GABA Synthesis, Release, Reuptake And Degradation Pathway (187174); Glutamate Neurotransmitter Release Cycle Pathway (106522); Insulin Processing Pathway (105903); Insulin Secretion Pathway (777534)

ncbi summary :

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

uniprot summary :

STX1A: a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described. Protein type: Vesicle; Membrane protein, integral. Chromosomal Location of Human Ortholog: 7q11.23. Cellular Component: SNARE complex; synaptic vesicle; neuron projection; synaptic vesicle membrane; plasma membrane; integral to membrane; extracellular region; actomyosin; endomembrane system; cell junction; cytosol; secretory granule. Molecular Function: protein binding, bridging; protein domain specific binding; SNAP receptor activity; myosin binding; protein N-terminus binding; calcium-dependent protein binding; ATP-dependent protein binding; protein binding; SNARE binding; chloride channel inhibitor activity; protein heterodimerization activity; myosin head/neck binding; calcium channel inhibitor activity; glycoprotein binding; kinase binding. Biological Process: response to gravity; neurotransmitter secretion; pathogenesis; positive regulation of neurotransmitter secretion; calcium ion-dependent exocytosis; synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; synaptic transmission; vesicle docking; cellular protein metabolic process; glutamate secretion; energy reserve metabolic process; regulation of insulin secretion; synaptic vesicle docking during exocytosis; positive regulation of exocytosis; secretion by cell

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage