protein

Synaptobrevin 1,1-91aa, Human, Recombinant, His- tag, E Coli

MBS203018

0.1 mg

310 USD

Recombinant Protein

Synaptobrevin 1,1-91aa, Human, Recombinant, His- tag, E Coli

Synaptobrevin 1

VAMP1; SYB1; Synaptobrevin 1; VAMP-1; Synaptobrevin-1; Vesicle-associated membrane protein 1; Vesicle-associated membrane protein 1 isoform 1 DKFZp686H12131; SYB 1; Synaptobrevin1; VAMP 1; Vesicle associated membrane protein 1; Vesicle associated membrane protein 1 synaptobrevin 1.

vesicle-associated membrane protein 1 isoform 1; Vesicle-associated membrane protein 1; vesicle-associated membrane protein 1; synaptobrevin 1; synaptobrevin-1; vesicle-associated membrane protein 1 (synaptobrevin 1); Synaptobrevin-1

VAMP1; VAMP1; SYB1; SPAX1; VAMP-1; SYB1; VAMP-1

VAMP1_HUMAN

118

MGSSHHHHHH SSGLVPRGSH MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY W

> 95% by SDS - PAGE

In Phosphate-buffered saline (pH 7.4), 1mM EDTA

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Neuroscience

Synaptobrevin 1(Vehicle-associated membrane, VAMP1) is one of the key proteins in the SNARE complex which is involved in regulated exocytosis. Synaptobrevin1 binds to t-SNAREs, syntaxin (STX) and SNAP25, after the fusion of synaptic vesicles to plasma membrane. Recombinant human Synaptobrevin1, fused to His- tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Nystuen AM., et al. (2007) Neurogenetics. 8:1-10. Pennuto M., et al. (2003) Mol Biol Cell. 14:4909-19.

7657673

NP_055046

NM_014231.4

11.9 kDa (111 aa), confirmed by MALDI-TOF.

Disease Pathway (530764); Neurotoxicity Of Clostridium Toxins Pathway (105734); SNARE Interactions In Vesicular Transport Pathway (83057); SNARE Interactions In Vesicular Transport Pathway (467); Toxicity Of Botulinum Toxin Type D (BoNT/D) Pathway (1127571); Toxicity Of Botulinum Toxin Type F (BoNT/F) Pathway (1127572); Toxicity Of Botulinum Toxin Type G (BoNT/G) Pathway (1127573); Uptake And Actions Of Bacterial Toxins Pathway (1127565)

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p. Cellular Component: SNARE complex; synaptic vesicle; mitochondrial outer membrane; neuron projection; cell surface; synaptic vesicle membrane; integral to plasma membrane; cytosol; cell junction. Molecular Function: SNAP receptor activity; SNARE binding; protein binding. Biological Process: vesicle fusion; exocytosis; pathogenesis. Disease: Spastic Ataxia 1, Autosomal Dominant

0.1 mg

310 USD

0.5 mg

720