protein

Synaptobrevin 2,1-89aa, Human, Recombinant, His- tag, E Coli

MBS203017

0.1 mg

310 USD

Recombinant Protein

Synaptobrevin 2,1-89aa, Human, Recombinant, His- tag, E Coli

Synaptobrevin 2

VAMP2; SYB2; Synaptobrevin 2; VAMP-2; Synaptobrevin-2; Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 FLJ11460; RATVAMPB; RATVAMPIR; SYB; VAMP 2; Vesicle associated membrane protein 2; Vesicle-associated membrane protein 2 (synaptobrevin 2).

vesicle-associated membrane protein 2; Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2); Synaptobrevin-2

VAMP2; VAMP2; SYB2; VAMP-2; SYB2; VAMP-2

VAMP2_HUMAN

116

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSA TAATAPPAAP AGEGGPPAPP PNLTSNRRLQ QTQAQVDEVV DIMRVNVDKV LERDQKLSEL DDRADALQAG ASQFETSAAKLKRKYW

> 95% by SDS - PAGE

Liquid. In Phosphate-buffered saline (pH 7.4), 1mM EDTA

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Neuroscience

Synaptobrevin 2(Vehicle-associated membrane, VAMP2), which is an 18 kDa integral membrane protein localized to the cytoplasmic surface of synaptic vesicle, consists of a proline-rich N-terminal region, a highly conserved hydrophilic domain, followed by a transmembrane anchor and a C-terminal. Synaptobrevin 2 is predominantly expressed in Langerhans islets and glomerular cells. The N-terminal domain of the protein (residues 1-89) forms a specific SNARE complex with the target membrane-associated t- or Q-SNAREs syntaxin 1 and SNAP-25.

Lin RC. and Scheller RH. (1997) Neuron. 19:1087-1094. Hanson PI. et al (1997) Cell 90:523-535. Scales SJ., et al. (2002) J Biol Chem. 277(31):28271-9. Windoffer R et al. (1999) Cell Tissue Res 296:499-510.

172072620

NP_055047

NM_014232.2

13.8 kDa (126 aa)

Acetylcholine Neurotransmitter Release Cycle Pathway (106525); Clathrin Derived Vesicle Budding Pathway (119545); Disease Pathway (530764); Dopamine Neurotransmitter Release Cycle Pathway (106523); Effects Of Botulinum Toxin Pathway (138028); GABA Synthesis, Release, Reuptake And Degradation Pathway (187174); Glutamate Neurotransmitter Release Cycle Pathway (106522); Golgi Associated Vesicle Biogenesis Pathway (119546); Insulin Signaling Pathway (198845); Insulin Processing Pathway (105903)

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

VAMP2: a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: zymogen granule membrane; neuron projection; intracellular membrane-bound organelle; clathrin-coated vesicle; synaptic vesicle membrane; integral to plasma membrane; secretory granule membrane; trans-Golgi network; cytosol; secretory granule; SNARE complex; synaptic vesicle; membrane; perinuclear region of cytoplasm; plasma membrane; synapse; cytoplasmic vesicle; cell junction. Molecular Function: calmodulin binding; SNAP receptor activity; protein binding; SNARE binding; protein self-association; syntaxin binding; syntaxin-1 binding; phospholipid binding; calcium-dependent protein binding. Biological Process: exocytosis; natural killer cell degranulation; neurotransmitter secretion; neutrophil degranulation; pathogenesis; calcium ion-dependent exocytosis; regulation of exocytosis; vesicle-mediated transport; vesicle fusion; synaptic transmission; synaptic vesicle exocytosis; protein transport; cellular protein metabolic process; glutamate secretion; cellular response to insulin stimulus; Golgi to plasma membrane protein transport; response to glucose stimulus; energy reserve metabolic process; eosinophil degranulation; protein complex assembly; post-Golgi vesicle-mediated transport; regulation of insulin secretion

0.1 mg

310 USD

0.5 mg

720