protein

Recombinant Keratin 14 (KRT14)

MBS2030164

0.01 mg

145 USD

Recombinant Protein

Recombinant Keratin 14 (KRT14)

[Keratin 14]

[keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 14; keratin, type I cytoskeletal 14; keratin 14, type I; Cytokeratin-14; CK-14; Keratin-14; K14]

[KRT14]

[KRT14; KRT14; K14; NFJ; CK14; EBS3; EBS4; CK-14; K14]

K1C14_HUMAN

E.coli

> 97%

20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose

Original Concentration: 90 ug/mL

Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE;Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

SDS-Page

Testing Data (TD)

Testing Data (TD)

Organism Species: Mus musculus (Mouse). Source: Prokaryotic expression. Residues: Met1~Asn484. Tags: N-terminal His Tag. Subcellular Location: Nucleus, Cytoplasm. Traits: Freeze-dried powder

Predicted isoelectric point: 5.1. Predicted Molecular Mass: 56.6 kDa. Accurate Molecular Mass: 57 kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

15431310

NP_000517.2

NM_000526.4

Corticotropin-releasing Hormone Pathway (920957); Glucocorticoid Receptor Regulatory Network Pathway (138014)

This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]

K14: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K5. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 17q21.2. Cellular Component: cytoplasm; keratin filament; intermediate filament; cytosol; nucleus. Molecular Function: protein binding; structural constituent of cytoskeleton. Biological Process: epidermis development; hemidesmosome assembly; epithelial cell differentiation; response to zinc ion; response to ionizing radiation; intermediate filament bundle assembly; hair cycle; aging. Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dermatopathia Pigmentosa Reticularis; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Naegeli Syndrome; Epidermolysis Bullosa Simplex, Dowling-meara Type

0.01 mg

145 USD

0.05 mg

270

0.1 mg

420

0.2 mg

515

0.5 mg

995

1 mg

1480