SNAP25 (Synaptosomal-associated protein) Human, His- tag, Recombinant, E Coli | MyBioSource MBS203015 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

SNAP25 (Synaptosomal-associated protein) Human, His- tag, Recombinant, E Coli

catalog :

MBS203015

quantity :

0.1 mg

price :

255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203015

products type :

Recombinant Protein

products full name :

SNAP25 (Synaptosomal-associated protein) Human, His- tag, Recombinant, E Coli

products short name :

SNAP25

products name syn :

SNAP25; SNAP; SNAP25; Synaptosomal-associated protein; His- tag; SNAP-25; Synaptosomal-associated 25 kDa protein; Super protein; SuP; Synaptosomal-associated protein 25; Synaptosomal-associated protein 25 isoform SNAP25B bA416N4.2; Bdr; dJ1068F16.2; FLJ23079; HGNC:11132; MGC105414; MGC139754; Resistance to inhibitors of cholinesterase 4 homolog; RIC 4; RIC4; SEC9; SNAP 25; SNAP-25B; SNP 25; sp; Synaptosomal associated 25 kDa protein; Synaptosomal associated protein; Synaptosomal Associated Protein 25; Synaptosomal associated protein 25kDa.

other names :

synaptosomal-associated protein 25 isoform SNAP25B; Synaptosomal-associated protein 25; synaptosomal-associated protein 25; SUP; resistance to inhibitors of cholinesterase 4 homolog; super protein; synaptosomal-associated protein, 25kD; synaptosomal-associated protein, 25kDa; Super protein; SUP; Synaptosomal-associated 25 kDa protein

products gene name :

SNAP25

other gene names :

SNAP25; SNAP25; RIC4; SEC9; SNAP; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2; SNAP; SNAP-25; SUP

uniprot entry name :

SNP25_HUMAN

sequence length :

206

sequence :

MGSSHHHHHH SSGLVPRGSH MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI EEGMDQINKD MKEAEKNLTD LGKFCGLCVC PCNKLKSSDA YKKAWGNNQD GVVASQPARV VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR IMEKADSNKT RIDEANQRAT KMLGSG

purity :

> 90% by SDS - PAGE

form :

Liquid. In 20mM Tris-HCl pH7.5, 50mM NaCl, 2mMDTT, 1mM EDTA

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Neuroscience

products description :

The synaptosomal-associated protein (SNAP-25) is an essential component of the core complex that mediates presynaptic vesicle trafficking. Thus, SNAP-25 is directly involved in the release of neurotransmitters. Recombinant human SNAP25, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Tafoya LC., et al. (2006) J. Neurosci. 26(30):7826-38. Schulz JR.,. (1998) J. Biol Chem. 273(38):24355-9.

ncbi gi num :

18765735

ncbi acc num :

NP_570824

ncbi gb acc num :

NM_130811.2

ncbi mol weight :

25.4 kDa (226 aa), confirmed by MALDI-TOF.

ncbi pathways :

Acetylcholine Neurotransmitter Release Cycle Pathway (106525); Disease Pathway (530764); Dopamine Neurotransmitter Release Cycle Pathway (106523); Effects Of Botulinum Toxin Pathway (138028); GABA Synthesis, Release, Reuptake And Degradation Pathway (187174); Glutamate Neurotransmitter Release Cycle Pathway (106522); Insulin Signaling Pathway (198845); Insulin Secretion Pathway (777534); Integration Of Energy Metabolism Pathway (106096); Metabolism Pathway (477135)

ncbi summary :

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

SNAP-25: a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Part of the SNARE core complex containing SNAP25, VAMP2 and syntaxin 1A. Associates with proteins involved in vesicle docking and membrane fusion. Two alternatively spliced isoforms have been described. Protein type: Vesicle. Chromosomal Location of Human Ortholog: 20p12-p11.2. Cellular Component: presynaptic membrane; SNARE complex; neuron projection; growth cone; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; trans-Golgi network; cytosol; cell junction; vesicle. Molecular Function: SNAP receptor activity; protein binding; syntaxin-1 binding; calcium-dependent protein binding. Biological Process: synaptic vesicle fusion to presynaptic membrane; synaptic transmission; synaptic vesicle exocytosis; glutamate secretion; neurotransmitter secretion; energy reserve metabolic process; neurotransmitter uptake; pathogenesis; regulation of insulin secretion; synaptic vesicle priming; synaptic vesicle docking during exocytosis. Disease: Myasthenic Syndrome, Congenital, 18

size1 :

0.1 mg

price1 :

255 USD

size2 :

0.5 mg

price2 :

535

more info or order :

MyBioSource product webpage