Recombinant Integrin Alpha M (ITGaM) | MyBioSource MBS2030077 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Integrin Alpha M (ITGaM)

catalog :

MBS2030077

quantity :

0.01 mg

price :

150 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2030077

products type :

Recombinant Protein

products full name :

Recombinant Integrin Alpha M (ITGaM)

products short name :

[Integrin Alpha M]

other names :

[integrin alpha-M isoform 1; Integrin alpha-M; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD_antigen: CD11b]

products gene name :

[ITGaM]

other gene names :

[ITGAM; ITGAM; CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; CD11B; CR3A]

uniprot entry name :

ITAM_HUMAN

host :

Host: E Coli. Source: Prokaryotic expression

sequence length :

1153

sequence :

The sequence of the target protein is listed below. NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM SQEGFSAAIT SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN DAYLGYAAAI ILRNRVQSLV LGAPRYQHIG LVAMFRQNTG MWESNANVKG T

purity :

>95%

form :

Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

image1 heading :

SDS-Page

other info1 :

Predicted isoelectric point: 6.8. Predicted Molecular Mass: 18.2kDa. Endotoxin: <1.0EU per 1ug (determined by the LAL method)

other info2 :

Expression System: Prokaryotic expression. Tag: N-terminal His-Tag. Organism Species: Homo sapiens (Human). Fragment: Arg48~Pro245. Usage: Reconstitute in sterile ddH2O.

ncbi gi num :

224831239

ncbi acc num :

NP_001139280.1

ncbi gb acc num :

NM_001145808.1

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Extracellular Matrix Organization Pathway (1270244); Focal Adhesion Pathway (198795); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Hemostasis Pathway (1269340)

ncbi summary :

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

uniprot summary :

ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: cell surface; plasma membrane; nucleus; integrin complex; external side of plasma membrane. Molecular Function: heparin binding; heparan sulfate proteoglycan binding; opsonin binding; protein binding; protein heterodimerization activity; metal ion binding; glycoprotein binding. Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; extracellular matrix organization and biogenesis; microglia development; activated T cell proliferation; leukocyte migration during inflammatory response; cellular extravasation; toll-like receptor signaling pathway; innate immune response; cell adhesion; blood coagulation; leukocyte migration; toll-like receptor 4 signaling pathway. Disease: Systemic Lupus Erythematosus, Susceptibility To, 6

size1 :

0.01 mg

price1 :

150 USD

size2 :

0.05 mg

price2 :

290

size3 :

0.1 mg

price3 :

455

size4 :

0.2 mg

price4 :

560

size5 :

0.5 mg

price5 :

1080

size6 :

1 mg

price6 :

1610

more info or order :

MyBioSource product webpage