protein

Recombinant Mannose Binding Lectin (MBL)

MBS2030072

0.01 mg

130 USD

Recombinant Protein

Recombinant Mannose Binding Lectin (MBL)

[Mannose Binding Lectin]

[mannose binding lectin, partial; Mannose-binding protein C; mannose-binding protein C; mannose-binding lectin (protein C) 2, soluble; Collectin-1; MBP1; Mannan-binding protein; Mannose-binding lectin]

[MBL]

[MBL2; MBL2; MBL; MBP; MBP1; MBPD; MBL2D; MBP-C; COLEC1; HSMBPC; COLEC1; MBL; MBP-C]

MBL2_HUMAN

E.coli

KV GKKYFVSSVK KMSLDRVKAL CSEFQGSVAT PRNAEENSAI QKVAKDIAYL GITDVRVEGS FEDLTGNRVR YTNWNDGEPN NTGDGEDCVV ILGNGKWNDV PCSDSFLAIC EFSD

>95%

20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.

Original Concentration: 500ug/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB)

(May be suitable for use in other assays to be determined by the end user.)

SDS-PAGE

Organism Species: Mus musculus (Mouse). Source: Prokaryotic expression. Residues: Lys129~Asp244. Tags: N-terminal His Tag. Subcellular Location: Secreted. Traits: Freeze-dried powder

Predicted isoelectric point: 6.4. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex

169335948

ACA48258.2

Predicted Molecular Mass: 16.4kDa. Accurate Molecular Mass: 16kDa as determined by SDS-PAGE reducing conditions.

Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (1269241); Creation Of C4 And C2 Activators Pathway (1269243); Immune System Pathway (1269170); Initial Triggering Of Complement Pathway (1269242); Innate Immune System Pathway (1269203); Lectin Pathway Of Complement Activation (1269244); Phagosome Pathway (153910); Phagosome Pathway (153859)

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]

MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 10q11.2. Cellular Component: extracellular space; collagen; cell surface; extracellular region. Molecular Function: mannose binding; protein binding; calcium ion binding; calcium-dependent protein binding; receptor binding. Biological Process: defense response to Gram-positive bacterium; killing by host of symbiont cells; positive regulation of phagocytosis; defense response to bacterium; acute-phase response; innate immune response; response to oxidative stress; opsonization; complement activation, lectin pathway; complement activation, classical pathway; negative regulation of viral reproduction; complement activation. Disease: Mannose-binding Protein Deficiency

0.01 mg

130 USD

0.05 mg

235

0.1 mg

355

0.2 mg

440

0.5 mg

845

1 mg

1250