Recombinant Vitronectin (VTN) | MyBioSource MBS2029640 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Vitronectin (VTN)

catalog :

MBS2029640

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

image

image 1 :

image 2 :

product information

catalog number :

MBS2029640

products type :

Recombinant Protein

products full name :

Recombinant Vitronectin (VTN)

products short name :

[Vitronectin]

other names :

[vitronectin; Vitronectin; vitronectin; vitronectin; S-protein; Serum-spreading factor; V75]

products gene name :

[VTN]

other gene names :

[VTN; VTN; VN; V75; VNT; VN]

uniprot entry name :

VTNC_HUMAN

host :

E.coli

reactivity :

Human

purity :

> 97%

form :

20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose and Proclin300.

concentration :

Original Concentration: 200ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

Sequence Information

image2 heading :

SDS-Page

other info1 :

Source: Prokaryotic expression. Residues: Ala19~Glu111. Tags: N-terminal His Tag. Subcellular Location: Secreted, Extracellular matrix. Traits: Freeze-dried powder

other info2 :

Predicted isoelectric point: 4.7. Predicted Molecular Mass: 11.6kDa. Accurate Molecular Mass: 19kDa as determined by SDS-PAGE reducing conditions. Phenomenon explanation: The possible reasons that the actual band size differs from the predicted are as follows:. 1.Splice variants: Alternative splicing may create different sized proteins from the same gene. 2. Relative charge: The composition of amino acids may affects the charge of the protein. 3. Post-translational modification: Phosphorylation, glycosylation, methylation etc. 4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleavedto give the active form. 5. Polymerization of the target protein: Dimerization, multimerization etc. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

88853069

ncbi acc num :

NP_000629.3

ncbi gb acc num :

NM_000638.3

ncbi pathways :

Complement Cascade Pathway (1269241); ECM Proteoglycans Pathway (1270256); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Elastic Fibre Formation Pathway (1270251); Extracellular Matrix Organization Pathway (1270244); FOXA1 Transcription Factor Network Pathway (137979); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478)

ncbi summary :

The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]

uniprot summary :

VTN: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Protein type: Secreted, signal peptide; Cell adhesion; Secreted; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 17q11. Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region. Molecular Function: heparin binding; integrin binding; protein binding; extracellular matrix binding; scavenger receptor activity; polysaccharide binding. Biological Process: receptor-mediated endocytosis; positive regulation of peptidyl-tyrosine phosphorylation; extracellular matrix organization and biogenesis; positive regulation of protein binding; cell-matrix adhesion; regulation of complement activation; negative regulation of blood coagulation; cell adhesion mediated by integrin; innate immune response; immune response; positive regulation of smooth muscle cell migration; cell adhesion; positive regulation of receptor-mediated endocytosis; positive regulation of vascular endothelial growth factor receptor signaling pathway

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

260

size3 :

0.1 mg

price3 :

400

size4 :

0.2 mg

price4 :

495

size5 :

0.5 mg

price5 :

955

size6 :

1 mg

price6 :

1415

more info or order :

MyBioSource product webpage