Recombinant Poliovirus Receptor Related Protein 2 (PVRL2) | MyBioSource MBS2029543 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Poliovirus Receptor Related Protein 2 (PVRL2)

catalog :

MBS2029543

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2029543

products type :

Recombinant Protein

products full name :

Recombinant Poliovirus Receptor Related Protein 2 (PVRL2)

products short name :

[Poliovirus Receptor Related Protein 2]

other names :

[poliovirus receptor related protein 2, partial; Nectin-2; nectin-2; poliovirus receptor-related 2 (herpesvirus entry mediator B); Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Poliovirus receptor-related protein 2; CD_antigen: CD112]

products gene name :

[PVRL2]

other gene names :

[PVRL2; PVRL2; HVEB; PRR2; CD112; PVRR2; HVEB; PRR2; Herpesvirus entry mediator B; HveB]

uniprot entry name :

PVRL2_HUMAN

host :

E Coli

purity :

>95%

concentration :

Original concentratrion: 200 ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8° C for one month. Aliquot and store at -80°C for 12 months. Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

tested application :

SDS-PAGE, Western Blot (WB), Positive Control, Immunogen

image1 heading :

SDS-Page

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Pro76~Ala353. Tags: N-terminal His Tag . Subcellular Location: Membrane. Traits: Freeze-dried powder. Predicted isoelectric point: 5.9. Predicted Molecular Mass: 33.7kDa. Accurate Molecular Mass: 40kDa as determined by SDS-PAGE reducing conditions. Buffer: 100mMNaHCO3, 500mMNaCl, pH8.3, containing 0.01% SKL, 5% Trehalose.

other info2 :

Phenomenon explanation: The possible reasons that the actual band size differs from the predicted are as follows. 1.Splice variants: Alternative splicing may create different sized proteins from the same gene. 2. Relative charge: The composition of amino acids may affects the charge of the protein. 3. Post-translational modification: Phosphorylation, glycosylation, methylation etc. 4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form. 5. Polymerization of the target protein: Dimerization, multimerization etc. Reconstitution: Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

4105702

ncbi acc num :

AAD02503.1

ncbi pathways :

Adaptive Immune System Pathway (1269171); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Adherens Junctions Interactions Pathway (1270234); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (1270232); Cell-Cell Communication Pathway (1270231); Cell-cell Junction Organization Pathway (1270233); Herpes Simplex Infection Pathway (377873)

ncbi summary :

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

nectin 2: Probable cell adhesion protein. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: focal adhesion; cell surface; plasma membrane; integral to membrane; zonula adherens; intercellular junction. Molecular Function: viral receptor activity; identical protein binding; protein binding; protein homodimerization activity; coreceptor activity; cell adhesion molecule binding. Biological Process: acrosome formation; establishment of mitochondrion localization; intercellular junction assembly and maintenance; regulation of immune response; sperm mitochondrion organization and biogenesis; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; spermatid nuclear differentiation; cytoskeleton organization and biogenesis; susceptibility to natural killer cell mediated cytotoxicity; signal transduction; virion attachment, binding of host cell surface coreceptor; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of mast cell activation; viral envelope fusion with host membrane; fertilization; cell part morphogenesis; adhesion to host; homophilic cell adhesion; spermatid development

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

260

size3 :

0.1 mg

price3 :

400

size4 :

0.2 mg

price4 :

495

size5 :

0.5 mg

price5 :

955

size6 :

1 mg

price6 :

1415

more info or order :

MyBioSource product webpage