protein

Recombinant Integrin Beta 6 (ITGb6)

MBS2029193

0.01 mg

140 USD

Recombinant Protein

Recombinant Integrin Beta 6 (ITGb6)

[Integrin Beta 6]

[integrin beta-6 isoform a; Integrin beta-6; integrin beta-6; integrin, beta 6]

[ITGb6]

[ITGB6; ITGB6; AI1H]

ITB6_HUMAN

E Coli

> 97%

Original Concentration: 200 ug/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control, Immunogen, SDS-PAGE, WB. (May be suitable for use in other assays to be determined by the end user.)

SDS-Page

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Tyr131~Leu371. Tags: N-terminal His Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder. Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.

Predicted isoelectric point: 4.8. Predicted Molecular Mass: 30.5kDa. Accurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

538916664

NP_001269282.1

NM_001282353.1

Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM Proteoglycans Pathway (1270256); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Elastic Fibre Formation Pathway (1270251); Extracellular Matrix Organization Pathway (1270244)

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ITGB6: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Belongs to the integrin beta chain family. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 2q24.2. Cellular Component: plasma membrane; integrin complex; receptor complex; external side of plasma membrane. Molecular Function: integrin binding; viral receptor activity. Biological Process: integrin-mediated signaling pathway; entry of virus into host cell; extracellular matrix organization and biogenesis; multicellular organismal development; cell-matrix adhesion; cell adhesion; inflammatory response. Disease: Amelogenesis Imperfecta, Type Ih

0.01 mg

140 USD

0.05 mg

260

0.1 mg

400

0.2 mg

495

0.5 mg

955

1 mg

1415