catalog number :
MBS2028546
products full name :
Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2A (CDKN2A)
products short name :
[Cyclin Dependent Kinase Inhibitor 2A]
other names :
[cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16; p16-INK4]
products gene name :
[CDKN2A]
other gene names :
[Cdkn2a; Cdkn2a; Arf; p16; MTS1; INK4A; p19ARF; p16Cdkn2a; CDK4I; p16; p16-INK4]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 24 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).
app notes :
Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Rattus norvegicus (Rat). Source: Polyclonal antibody preparation. Traits: Liquid
other info2 :
Immunogen: Recombinant CDKN2A (Ser3~Pro155) expressed in E.coli
ncbi acc num :
NP_113738.1
ncbi gb acc num :
NM_031550.1
ncbi pathways :
Apoptosis Pathway (219785); Bladder Cancer Pathway (83503); Bladder Cancer Pathway (527); Cell Cycle Pathway (1010258); Cell Cycle, Mitotic Pathway (1010278); Cell Cycle Pathway (198428); Cell Cycle Pathway (83446); Cell Cycle Pathway (463); Cellular Senescence Pathway (1010386); Cellular Responses To Stress Pathway (1010374)
ncbi summary :
tumor suppressor that inhibits CDK4; inactivation or loss is associated with cellular transformation; may be involved in CNS degeneration following injury [RGD, Feb 2006]
uniprot summary :
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein ().