catalog number :
MBS2028432
products full name :
Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP)
products short name :
[Lipopolysaccharide]
other names :
[lipopolysaccharide-binding protein; Lipopolysaccharide binding protein; lipopolysaccharide-binding protein; Lipopolysaccharide binding protein]
products gene name :
[LBP]
other gene names :
[LBP; LBP; LPSBP]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
concentration :
0.5 mg/ml
storage stability :
Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP)
app notes :
Western blotting: 0.5-2 ug/mL;1:250-1000. Immunohistochemistry: 5-20 ug/mL;1:25-100. Immunocytochemistry: 5-20 ug/mL;1:25-100. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
other info1 :
Organism Species: Sus scrofa; Porcine (Pig). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant LBP (Asn36~Thr474) expressed in E.coli
ncbi acc num :
NP_001121907.1
ncbi gb acc num :
NM_001128435.1
ncbi pathways :
Immune System Pathway (1381108); Innate Immune System Pathway (1381138); NF-kappa B Signaling Pathway (634542); NF-kappa B Signaling Pathway (634652); Regulation Of TLR By Endogenous Ligand Pathway (1427779); Salmonella Infection Pathway (375169); Salmonella Infection Pathway (375149); Toll Like Receptor 4 (TLR4) Cascade Pathway (1381164); Toll-Like Receptors Cascades Pathway (1381139); Toll-like Receptor Signaling Pathway (84488)
uniprot summary :
Plays a role in the innate immune response (PubMed:2402637). Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:2427635). Acts as an affinity enhancer for CD14, facilitating its association with LPS (). Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:2402637).