Polyclonal Antibody to Receptor Tyrosine Kinase Like Orphan Receptor 2 (ROR2) | MyBioSource MBS2028051 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Receptor Tyrosine Kinase Like Orphan Receptor 2 (ROR2)

catalog :

MBS2028051

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot; Sample: Human Hela cell lysate;. Primary Ab: 1µg/ml Rabbit Anti-Human ROR2 Antibody. Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody. (Catalog: MBS2086047)

image 2 :

Western Blot;. Sample: Recombinant ROR2, Human.

image 3 :

DAB staining on IHC-P; Samples: Human Stomach Tissue;. Primary Ab: 20ug/ml Rabbit Anti-Human ROR2 Antibody Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)

product information

catalog number :

MBS2028051

products type :

Antibody

products full name :

Polyclonal Antibody to Receptor Tyrosine Kinase Like Orphan Receptor 2 (ROR2)

products short name :

[Receptor Tyrosine Kinase Like Orphan Receptor 2]

other names :

[tyrosine-protein kinase transmembrane receptor ROR2 isoform 2; Tyrosine-protein kinase transmembrane receptor ROR2; tyrosine-protein kinase transmembrane receptor ROR2; receptor tyrosine kinase like orphan receptor 2; Neurotrophic tyrosine kinase, receptor-related 2]

products gene name :

[ROR2]

other gene names :

[ROR2; ROR2; BDB; BDB1; NTRKR2; NTRKR2]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

0.35 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).

app notes :

Western blotting: 0.5-2 ug/mL;1:170-700. Immunohistochemistry: 5-20 ug/mL;1:17-70. Immunocytochemistry: 5-20 ug/mL;1:17-70. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant ROR2 (Trp683~Val934) expressed in E.coli

other info2 :

Conjugate: No Conjugate. Immunogen: Recombinant ROR2 (Trp683~Val934) expressed in E Coli. Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2074331

ncbi gi num :

970598266

ncbi acc num :

NP_001305133.1

ncbi gb acc num :

NM_001318204.1

uniprot acc num :

Q01974

ncbi pathways :

Beta-catenin Independent WNT Signaling Pathway (1269610); Cardiac Progenitor Differentiation Pathway (712094); Noncanonical Wnt Signaling Pathway (169354); PCP/CE Pathway (1269611); Signal Transduction Pathway (1269379); Signaling By Wnt Pathway (1269594); WNT5A-dependent Internalization Of FZD2, FZD5 And ROR2 Pathway (1269614); Wnt Signaling Pathway NetPath (198799); Wnt Signaling Network Pathway (137962)

ncbi summary :

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]

uniprot summary :

ROR2: a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ror family; TK group. Chromosomal Location of Human Ortholog: 9q22.31. Cellular Component: cell soma; cell surface; dendrite; integral component of plasma membrane; microtubule; plasma membrane. Molecular Function: ATP binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; frizzled binding; metal ion binding; protein binding; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding. Biological Process: astrocyte development; BMP signaling pathway; bone mineralization; cartilage condensation; cell fate commitment; embryonic digit morphogenesis; embryonic genitalia morphogenesis; inner ear morphogenesis; JNK cascade; macrophage migration; male genitalia development; multicellular organism development; negative regulation of canonical Wnt signaling pathway; negative regulation of cell proliferation; peptidyl-tyrosine phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of JUN kinase activity; positive regulation of macrophage differentiation; positive regulation of protein kinase C activity; positive regulation of synaptic transmission, glutamatergic; positive regulation of transcription, DNA-templated; signal transduction; smoothened signaling pathway; somitogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway. Disease: Brachydactyly, Type B1; Robinow Syndrome, Autosomal Recessive

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

130

size3 :

0.05 mg

price3 :

175

size4 :

0.1 mg

price4 :

225

size5 :

0.2 mg

price5 :

340

size6 :

1 mg

price6 :

800

more info or order :

MyBioSource product webpage