Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1) | MyBioSource MBS2027954 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1)

catalog :

MBS2027954

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant LRP1, Mouse.

image 2 :

DAB staining on fromalin fixed paraffin-embedded Liver tissue)

product information

catalog number :

MBS2027954

products type :

Antibody

products full name :

Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 1 (LRP1)

products short name :

[Low Density Lipoprotein Receptor Related Protein 1]

other names :

[prolow-density lipoprotein receptor-related protein 1; Prolow-density lipoprotein receptor-related protein 1; prolow-density lipoprotein receptor-related protein 1; low density lipoprotein receptor-related protein 1; Alpha-2-macroglobulin receptor; A2MR]

products gene name :

[LRP1]

other gene names :

[Lrp1; Lrp1; Lrp; A2mr; CD91; AI316852; b2b1554Clo; LRP-1; A2MR; LRP-85; LRP-515; LRPICD]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

specificity :

The antibody is a Rabbit polyclonal antibody raised against LRP1. It has been selected for its ability to recognize LRP1 in immunohistochemical staining and western blotting.

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP

app notes :

Western blotting: 0.5-2µg/mL. Immunocytochemistry in formalin fixed cells: 5-20µg/mL. Immunohistochemistry in formalin fixed frozen section: 5-20µg/mL. Immunohistochemistry in paraffin section: 5-20µg/mL. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant LRP1 (Ile692~Cys962) expressed in E.coli.

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2050434

ncbi gi num :

124494256

ncbi acc num :

NP_032538.2

ncbi gb acc num :

NM_008512.2

uniprot acc num :

Q91ZX7

ncbi mol weight :

504,742 Da

ncbi pathways :

Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (1458482); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1367201); Malaria Pathway (152666); Malaria Pathway (152657); Metabolism Pathway (1367614); Metabolism Of Fat-soluble Vitamins Pathway (1367813); Metabolism Of Vitamins And Cofactors Pathway (1367799); Retinoid Metabolism And Transport Pathway (1367135)

uniprot summary :

LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung. Protein type: Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Chromosomal Location of Human Ortholog: 10 10 D3. Cellular Component: basolateral plasma membrane; cell soma; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytosol; dendrite; early endosome; endosome; focal adhesion; integral component of membrane; integral component of plasma membrane; lysosomal membrane; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex. Molecular Function: alpha-2 macroglobulin receptor activity; apolipoprotein binding; calcium ion binding; clathrin heavy chain binding; metal ion binding; protease binding; protein binding; protein complex binding; RNA binding. Biological Process: apoptotic cell clearance; astrocyte activation during immune response; cardiac septum development; cell proliferation; cellular response to amyloid-beta; cholesterol metabolic process; endocytosis; multicellular organism development; negative regulation of neuron apoptosis; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of smooth muscle cell migration; negative regulation of Wnt signaling pathway; positive regulation of amyloid-beta clearance; positive regulation of cell death; positive regulation of cholesterol efflux; positive regulation of endocytosis; positive regulation of lipid transport; positive regulation of lysosomal protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein transport; protein kinase C-activating G-protein coupled receptor signaling pathway; receptor-mediated endocytosis; regulation of actin cytoskeleton organization; regulation of cholesterol transport; regulation of phospholipase A2 activity; regulation of protein metabolic process; transcytosis

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

125

size3 :

0.05 mg

price3 :

175

size4 :

0.1 mg

price4 :

225

size5 :

0.2 mg

price5 :

330

size6 :

1 mg

price6 :

785

more info or order :

MyBioSource product webpage