Polyclonal Antibody to Cell Adhesion Molecule With Homology To L1CAM (CHL1) | MyBioSource MBS2027861 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Cell Adhesion Molecule With Homology To L1CAM (CHL1)

catalog :

MBS2027861

quantity :

0.01 mg

price :

115 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant protein.

image 2 :

DABstainingonIHC-P.Samples:HumanTissue)

product information

catalog number :

MBS2027861

products type :

Antibody

products full name :

Polyclonal Antibody to Cell Adhesion Molecule With Homology To L1CAM (CHL1)

products short name :

[Cell Adhesion Molecule With Homology To L1CAM]

other names :

[neural cell adhesion molecule L1-like protein isoform 2; Neural cell adhesion molecule L1-like protein; neural cell adhesion molecule L1-like protein; cell adhesion molecule L1 like; Close homolog of L1]

products gene name :

[CHL1]

other gene names :

[CHL1; CHL1; CALL; L1CAM2; CALL]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

0.22 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).

app notes :

Western blotting: 0.5-2 ug/mL;1:110-440. Immunohistochemistry: 5-20 ug/mL;1:11-44. Immunocytochemistry: 5-20 ug/mL;1:11-44. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant CHL1 (Pro35~Glu328) expressed in E.coli

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2084782

ncbi gi num :

358438179

ncbi acc num :

NP_001240316.1

ncbi gb acc num :

NM_001253387.1

uniprot acc num :

O00533

ncbi pathways :

Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); Developmental Biology Pathway (477129); L1CAM Interactions Pathway (161003)

ncbi summary :

The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011]

uniprot summary :

CHL1: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Cell development/differentiation; Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 3p26.3. Cellular Component: apical part of cell; dendrite; integral component of membrane; plasma membrane; proteinaceous extracellular matrix. Molecular Function: protease binding. Biological Process: adult locomotory behavior; axon guidance; axon regeneration; cell adhesion; cognition; negative regulation of neuron apoptosis; neuron migration; signal transduction

size1 :

0.01 mg

price1 :

115 USD

size2 :

0.02 mg

price2 :

135

size3 :

0.05 mg

price3 :

190

size4 :

0.1 mg

price4 :

245

size5 :

0.2 mg

price5 :

370

size6 :

1 mg

price6 :

875

more info or order :

MyBioSource product webpage