Polyclonal Antibody to Oncostatin M Receptor (OSMR) | MyBioSource MBS2027787 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Oncostatin M Receptor (OSMR)

catalog :

MBS2027787

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Sample: Recombinant OSMR, Mouse.

image 2 :

DAB staining on fromalin fixed paraffin- embedded Kidney tissue)

product information

catalog number :

MBS2027787

products type :

Antibody

products full name :

Polyclonal Antibody to Oncostatin M Receptor (OSMR)

products short name :

[Oncostatin M]

other names :

[oncostatin-M-specific receptor subunit beta isoform 2; Oncostatin-M-specific receptor subunit beta; oncostatin-M-specific receptor subunit beta; oncostatin M receptor; Interleukin-31 receptor subunit beta; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB]

products gene name :

[OSMR]

other gene names :

[Osmr; Osmr; OSMRB; Osmrb; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

1mg/ml

storage stability :

Storage:. Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 24 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP)

app notes :

Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Organism Species: Mus musculus (Mouse). Source: Polyclonal antibody preparation. Traits: Liquid

other info2 :

Immunogen: Recombinant OSMR (Trp410~Gly652) expressed in E.coli ( MBS2031280 ).

ncbi gi num :

881526059

ncbi acc num :

NP_001297398.1

ncbi gb acc num :

NM_001310469.1

uniprot acc num :

O70458

ncbi pathways :

Cytokine Signaling In Immune System Pathway (1323763); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); IL-6-type Cytokine Receptor Ligand Interactions Pathway (1323779); Immune System Pathway (1323639); Interleukin-6 Family Signaling Pathway (1323778); Jak-STAT Signaling Pathway (83274); Jak-STAT Signaling Pathway (488); PI3K-Akt Signaling Pathway (692242); PI3K-Akt Signaling Pathway (692979)

uniprot summary :

OSMR: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1); also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 15 A1 15 3.3 cM. Cellular Component: apical plasma membrane; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; membrane; oncostatin-M receptor complex. Molecular Function: cytokine binding; growth factor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; oncostatin-M receptor activity. Biological Process: cell surface receptor signaling pathway; oncostatin-M-mediated signaling pathway; positive regulation of cell proliferation; response to cytokine

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

125

size3 :

0.05 mg

price3 :

175

size4 :

0.1 mg

price4 :

225

size5 :

0.2 mg

price5 :

330

size6 :

1 mg

price6 :

785

more info or order :

MyBioSource product webpage