catalog number :
MBS2027772
products full name :
Polyclonal Antibody to Complement Component 9 (C9)
products short name :
[Complement Component 9]
other names :
[complement component C9; Complement component C9; complement component C9; complement component 9]
products gene name :
[C9]
other gene names :
[C9; C9]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
storage stability :
Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test:The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Western blotting (WB);Immunohistochemistry (IHC);Immunocytochemistry (ICC);Immunoprecipitation IP
app notes :
Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Mus musculus (Mouse). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant Complement Component 9 (Pro136~Arg512)expressed in E.coli.
ncbi acc num :
NP_038513.1
ncbi gb acc num :
NM_013485.1
ncbi pathways :
Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Complement Activation, Classical Pathway (198379); Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (575148); Immune System Pathway (575095); Innate Immune System Pathway (575115); Prion Diseases Pathway (101157)
uniprot summary :
C9: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Defects in C9 are a cause of complement component 9 deficiency (C9D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. Protein type: Apoptosis; Extracellular matrix; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 15 15 A1. Cellular Component: cytosol; extracellular region; extracellular space; integral component of membrane; membrane; membrane attack complex; plasma membrane. Biological Process: blood coagulation; cell killing; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; immune response; immune system process; innate immune response; protein homooligomerization