antibody

Polyclonal Antibody to Annexin A1 (ANXA1)

MBS2027664

0.1 mg

245 USD

polyclonal

guinea pigs

nonconjugated

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

Antibody

Polyclonal Antibody to Annexin A1 (ANXA1)

[Annexin A1]

[Annexin A1; Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Lipocortin-like 33 kDa protein; Phospholipase A2 inhibitory protein; p35]

[ANXA1]

[ANXA1; ANX1]

ANXA1_CAVCU

Polyclonal

Guinea pig

346

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

0.27 mg/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

WB; IHC; ICC; IP.

Western blotting: 0.5-2 ug/mL;1:130-540. Immunohistochemistry: 5-20 ug/mL;1:13-54. Immunocytochemistry: 5-20 ug/mL;1:13-54. Optimal working dilutions must be determined by end user.

Western Blot (WB)

Fragment: ANXA1 (Met1~Asn346). Organism Species: Oryctolagus cuniculus (Rabbit)

Conjugate: No Conjugate. Immunogen: Recombinant ANXA1 (Met1~Asn346) expressed in E Coli.

113942

P14087.1

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (). Has high affinity for Ca2+ and can bind up to eight Ca2+ ions (). Displays Ca2+-dependent binding to phospholipid membranes (PubMed:2962884). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton ().

0.1 mg

245 USD