Polyclonal Antibody to Transforming Growth Factor Beta Receptor II (TGFbR2) | MyBioSource MBS2027588 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Transforming Growth Factor Beta Receptor II (TGFbR2)

catalog :

MBS2027588

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Human HepG2 cell lysate; Primary Ab: 1ug/ml Rabbit Anti-Mouse TGFbR2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody

image 2 :

Western Blot: Sample: Recombinant protein.

image 3 :

DAB staining on IHC-P. Samples: Mouse Tissue)

product information

catalog number :

MBS2027588

products type :

Antibody

products full name :

Polyclonal Antibody to Transforming Growth Factor Beta Receptor II (TGFbR2)

products short name :

[Transforming Growth Factor Beta Receptor II]

other names :

[TGF-beta receptor type-2 isoform 1; TGF-beta receptor type-2; TGF-beta receptor type-2; transforming growth factor, beta receptor II; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II]

products gene name :

[TGFbR2]

other gene names :

[Tgfbr2; Tgfbr2; DNIIR; RIIDN; TBR-II; AU042018; TbetaRII; TbetaR-II; 1110020H15Rik; TGFR-2; TGF-beta receptor type II; TbetaR-II]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

specificity :

The antibody is a Rabbit polyclonal antibody raised against TGFbR2. It has been selected for its ability to recognize TGFbR2 in immunohistochemical staining and western blotting.

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition

tested application :

WB; IHC; ICC; IP

app notes :

Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant TGFbR2 (Ile209~Thr590) expressed in E.coli

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2069232

ncbi gi num :

239787881

ncbi acc num :

NP_033397.3

ncbi gb acc num :

NM_009371.3

uniprot acc num :

Q62312

ncbi mol weight :

64,219 Da

ncbi pathways :

AGE-RAGE Signaling Pathway In Diabetic Complications (1320037); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Adherens Junction Pathway (83267); Adherens Junction Pathway (481); Chagas Disease (American Trypanosomiasis) Pathway (147810); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chronic Myeloid Leukemia Pathway (83309); Chronic Myeloid Leukemia Pathway (528); Colorectal Cancer Pathway (83299); Colorectal Cancer Pathway (518)

uniprot summary :

TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer. Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily. Chromosomal Location of Human Ortholog: 9 F3 9 68.39 cM. Cellular Component: caveola; cell surface; cytoplasm; cytosol; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane; receptor complex. Molecular Function: ATP binding; glycosaminoglycan binding; kinase activity; metal ion binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor activity; signal transducer, downstream of receptor, with serine/threonine kinase activity; SMAD binding; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; type I transforming growth factor beta receptor binding; type III transforming growth factor beta receptor binding. Biological Process: activation of protein kinase activity; apoptosis; atrioventricular valve morphogenesis; brain development; branching involved in blood vessel morphogenesis; cardiac left ventricle morphogenesis; cartilage development; cell differentiation; cell proliferation involved in endocardial cushion morphogenesis; common-partner SMAD protein phosphorylation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; endocardial cushion fusion; gastrulation; growth plate cartilage chondrocyte growth; growth plate cartilage development; heart development; heart looping; in utero embryonic development; inferior endocardial cushion morphogenesis; lens development in camera-type eye; lung development; membranous septum morphogenesis; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of cell proliferation; Notch signaling pathway; organ morphogenesis; outflow tract morphogenesis; outflow tract septum morphogenesis; palate development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of reactive oxygen species metabolic process; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; receptor-mediated endocytosis; regulation of cell proliferation; regulation of gene expression; regulation of growth; response to drug; smoothened signaling pathway; superior endocardial cushion morphogenesis; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; tricuspid valve morphogenesis; vasculogenesis

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

130

size3 :

0.05 mg

price3 :

185

size4 :

0.1 mg

price4 :

230

size5 :

0.2 mg

price5 :

345

size6 :

1 mg

price6 :

825

more info or order :

MyBioSource product webpage