product summary
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company name :
MyBioSource
product type :
antibody
product name :
Polyclonal Antibody to N-Acetyl Alpha-D-Glucosaminidase (NAGLU)
catalog :
MBS2027566
quantity :
0.01 mg
price :
135 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, enzyme immunoassay, immunohistochemistry - paraffin section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2027566
products type :
Antibody
products full name :
Polyclonal Antibody to N-Acetyl Alpha-D-Glucosaminidase (NAGLU)
products short name :
N-Acetyl Alpha-D-Glucosaminidase
other names :
Naglu; Naglu; alpha-N-acetylglucosaminidase; alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB); Naglu
products gene name :
NAGLU
other gene names :
Naglu; Naglu
uniprot entry name :
O54752_MOUSE
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
739
sequence :
The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- VSHPDA GAAWRLLLRS VYNCSGEACR GHNRSPLVRR PSLQMNTSIW YNRSDVFEAW RLLLTSAPSL ATSPAFRYDL LDLTRQAVQE LVSLYYEEAR SAYLSKELAS LLRAGGVLAY ELLPALDEVL ASDSRFLLGS WLEQARAAAV SEAEADFYEQ NSRYQLTLWG PEGNILDYAN KQLAGLVANY YTPRWRLFLE ALVDSVAQGI PFQQHQFDKN VFQLEQAFVL SKQRYPSQPR GDTVDLAKKI FLKYYPRWVA
specificity :
The antibody is a rabbit polyclonal antibody raised against NAGLU. It has beenselected for its ability to recognize NAGLU in immunohistochemical staining andwestern blotting.
purity :
Antigen-specific Affinity Chromatography.
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
concentration :
200ug/ml
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition
tested application :
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA), IP, IF, FCM.
app notes :
Western blotting: 0.5-2ug/ml. Immunocytochemistry in formalin fixed cells: 5-20ug/ml. Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml. Immunohistochemistry in paraffin section: 5-20ug/ml. Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml. Optimal working dilutions must be determined by end user.
other info1 :
Fragment: NAGLU (Val485~Trp743). Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation
other info2 :
Conjugate: No Conjugate. Immunogen: Recombinant N-Acetyl Alpha-D-Glucosaminidase (NAGLU). Traits: Liquid
ncbi gi num :
2660688
ncbi acc num :
AAB88084.1
ncbi mol weight :
82,610 Da
ncbi pathways :
Glycosaminoglycan Degradation Pathway (83180); Glycosaminoglycan Degradation Pathway (355); Glycosaminoglycan Metabolism Pathway (1254288); HS-GAG Degradation Pathway (1254299); Heparan Sulfate Degradation Pathway (421777); Heparan Sulfate Degradation Pathway (468270); Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway (1254296); Lysosome Pathway (99272); Lysosome Pathway (96865); Metabolic Pathways (132962)
uniprot summary :
NAGLU: Involved in the degradation of heparan sulfate. Defects in NAGLU are the cause of mucopolysaccharidosis type 3B (MPS3B); also known as Sanfilippo syndrome B. MPS3B is a form of mucopolysaccharidosis type 3, an autosomal recessive lysosomal storage disease due to impaired degradation of heparan sulfate. MPS3 is characterized by severe central nervous system degeneration, but only mild somatic disease. Onset of clinical features usually occurs between 2 and 6 years; severe neurologic degeneration occurs in most patients between 6 and 10 years of age, and death occurs typically during the second or third decade of life. Protein type: Hydrolase; EC 3.2.1.50; Glycan Metabolism - glycosaminoglycan degradation. Molecular Function: alpha-N-acetylglucosaminidase activity. Biological Process: locomotor rhythm; retinal rod cell development; inner ear receptor cell development; lysosome organization and biogenesis; cerebellar Purkinje cell layer development; middle ear morphogenesis
size1 :
0.01 mg
price1 :
135 USD
size2 :
0.05 mg
price2 :
235
size3 :
0.1 mg
price3 :
320
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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