catalog number :
MBS2027061
products full name :
Polyclonal Antibody to Secretogranin III (SCG3)
products short name :
[Secretogranin III]
other names :
[secretogranin-3 isoform 2; Secretogranin-3; secretogranin-3; secretogranin III; Secretogranin III; SgIII]
products gene name :
[SCG3]
other gene names :
[SCG3; SCG3; SGIII; SgIII]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300,50% glycerol.
concentration :
0.71 mg/ml
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the
expiration date under appropriate storage condition.
tested application :
WB; IHC; ICC; IP.
app notes :
Western blotting: 0.5-2 Ug/mL;1:350-1400. Immunohistochemistry: 5-20 Ug/mL;1:35-140. Immunocytochemistry: 5-20 Ug/mL;1:35-140. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant SCG3 (Phe20~Leu468) expressed in E.coli
other info2 :
Conjugate: No Conjugate. Immunogen: Recombinant SCG3 (Phe20~Leu468) expressed in E Coli. Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2077300
ncbi acc num :
NP_001158729.1
ncbi gb acc num :
NM_001165257.1
ncbi pathways :
Hemostasis Pathway (106028); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)
ncbi summary :
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
uniprot summary :
SCG3: 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 15q21.2. Cellular Component: endoplasmic reticulum lumen; extracellular region. Molecular Function: RNA binding. Biological Process: cellular protein metabolic process; platelet degranulation; post-translational protein modification