catalog number :
MBS2026867
products full name :
Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1)
products short name :
[Membrane Spanning 4 Domains Subfamily A]
other names :
[B-lymphocyte antigen CD20; B-lymphocyte antigen CD20; B-lymphocyte antigen CD20; membrane-spanning 4-domains, subfamily A, member 1; B-cell differentiation antigen Ly-44; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20]
products gene name :
[MS4A1]
other gene names :
[Ms4a1; Ms4a1; Cd20; Ly-44; Ms4a2; AA960661; Cd20; Ly-44; Ms4a2]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
concentration :
0.7 mg/ml
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).
app notes :
Western blotting: 0.5-2 ug/mL;1:350-1400. Immunohistochemistry: 5-20 ug/mL;1:35-140. Immunocytochemistry: 5-20 ug/mL;1:35-140. Optimal working dilutions must be determined by end user
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Mus musculus (Mouse). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant CD20 (Pro6~Lys251) expressed in E.coli
ncbi acc num :
NP_031667.1
ncbi gb acc num :
NM_007641.5
ncbi pathways :
Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489)
uniprot summary :
MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family. Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 19 A 19 8.19 cM. Cellular Component: external side of plasma membrane; extracellular exosome; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane. Molecular Function: epidermal growth factor receptor binding; protein binding. Biological Process: B cell activation