Polyclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) | MyBioSource MBS2026729 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Fibroblast Activation Protein Alpha (FAPa)

catalog :

MBS2026729

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Mouse Testis Tissue.

image 2 :

Western Blot: Sample: Recombinant FAPa, Mouse.

image 3 :

DAB staining on IHC-P; Samples: Mouse Testis Tissue.

product information

catalog number :

MBS2026729

products type :

Antibody

products full name :

Polyclonal Antibody to Fibroblast Activation Protein Alpha (FAPa)

products short name :

[Fibroblast Activation Protein Alpha]

other names :

[prolyl endopeptidase FAP; Prolyl endopeptidase FAP; prolyl endopeptidase FAP; fibroblast activation protein; Dipeptidyl peptidase FAP]

products gene name :

[FAPa]

other gene names :

[Fap; Fap; SIMP; APCE]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

0.89 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP.

app notes :

Western blotting: 0.5-2 ug/mL;1:450-1800. Immunohistochemistry: 5-20 ug/mL;1:45-180. Immunocytochemistry: 5-20 ug/mL;1:45-180. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

DAB staining on IHC-P; Samples: Mouse Uterus Tissue

image5 heading :

Immunohistochemistry (IHC)

image5 description :

DAB staining on IHC-P; Samples: Mouse Stomach Tissue.

other info1 :

Organism Species: Mus musculus (Mouse). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant FAPa (Gly542~Asp761) expressed in E.coli

other info2 :

Conjugate: No Conjugate. Immunogen: Recombinant FAPa (Gly542~Asp761) expressed in E Coli. Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2065903

ncbi gi num :

6679749

ncbi acc num :

NP_032012.1

ncbi gb acc num :

NM_007986.3

uniprot acc num :

P97321

ncbi summary :

This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]

uniprot summary :

FAP: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.14.5; EC 3.4.21.26; Membrane protein, integral; Protease. Chromosomal Location of Human Ortholog: 2 C1.3 2 35.85 cM. Cellular Component: apical part of cell; cell junction; cell projection; cell surface; extracellular region; extracellular space; focal adhesion; integral component of membrane; invadopodium membrane; lamellipodium; membrane; plasma membrane. Molecular Function: dipeptidyl-peptidase activity; endopeptidase activity; hydrolase activity; integrin binding; peptidase activity; protease binding; protein homodimerization activity; serine-type endopeptidase activity; serine-type peptidase activity. Biological Process: angiogenesis; apoptosis; cell adhesion; endothelial cell migration; melanocyte apoptotic process; melanocyte proliferation; mitotic cell cycle arrest; negative regulation of extracellular matrix disassembly; positive regulation of cell cycle arrest; positive regulation of execution phase of apoptosis; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of collagen catabolic process

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

130

size3 :

0.05 mg

price3 :

185

size4 :

0.1 mg

price4 :

230

size5 :

0.2 mg

price5 :

345

size6 :

1 mg

price6 :

825

more info or order :

MyBioSource product webpage