catalog number :
MBS2026361
products full name :
Polyclonal Antibody to Transferrin Receptor (TFR)
products short name :
[Transferrin Receptor]
other names :
[transferrin receptor protein 1; Transferrin receptor protein 1; transferrin receptor protein 1; transferrin receptor]
products gene name :
[TFR]
other gene names :
[TFRC; TFRC; TR; TfR; TfR1; Trfr]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
concentration :
0.23 mg/ml
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the
expiration date under appropriate storage condition.
tested application :
WB; IHC; ICC; IP.
app notes :
Western blotting: 0.5-2 Ug/mL;1:110-450. Immunohistochemistry: 5-20) Ug/mL;1:11-45. Immunocytochemistry: 5-20)Ug/mL;1:11-45.
Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
other info1 :
Organism Species: Chicken (Gallus). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant TFR (Thr585~Lys771) expressed in E.coli
ncbi acc num :
NP_990587.2
ncbi gb acc num :
NM_205256.2
ncbi pathways :
Endocytosis Pathway (102290); Endocytosis Pathway (102181); Phagosome Pathway (153918); Phagosome Pathway (153859)
uniprot summary :
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system ().